Complement factor H in molecular regulation of angiogenesis
Abstract: Angiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes. Complement factor H (CFH) is a plasma protein that inhibits the alternative pathway of the complement system. Loss of CFH enhances the alternative pathway and increases complement activation fragments with pro-angiogenic capacity, including complement 3a, complement 5a, and membrane attack complex. CFH protein contains binding sites for C-reactive protein, malondialdehyde, and endothelial heparan sulfates. Dysfunction of CFH prevents its interaction with these molecules and initiates pro-angiogenic events. Mutations in the CFH gene have been found in patients with age-related macular degeneration characterized by choroidal neovascularization. The Cfh-deficient mice show an increase in angiogenesis, which is decreased by administration of recombinant CFH protein. In this review, we summarize the molecular mechanisms of the anti-angiogenic effects of CFH and the regulatory mechanisms of CFH expression. The therapeutic potential of recombinant CFH protein in angiogenesis-related diseases has also been discussed.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Complement factor H in molecular regulation of angiogenesis ; volume:4 ; number:5 ; year:2024 ; pages:452-466 ; extent:015
Medical Review ; 4, Heft 5 (2024), 452-466 (gesamt 015)
- Creator
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Li, Jiang
Wang, Kaili
Starodubtseva, Maria N.
Nadyrov, Eldar
Kapron, Carolyn M.
Hoh, Josephine
Liu, Ju
- DOI
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10.1515/mr-2023-0048
- URN
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urn:nbn:de:101:1-2410231536301.054079218805
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Li, Jiang
- Wang, Kaili
- Starodubtseva, Maria N.
- Nadyrov, Eldar
- Kapron, Carolyn M.
- Hoh, Josephine
- Liu, Ju
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