Four Years’ Follow-Up Study of Liver Function of Haemophiliacs

By physical and biochemical examinations 112 patients with severe haemophilia A or B and 24 with mild to moderate forms were studied to determine the incidence of liver damage, which may have resulted from commercial concentrate therapy. Data of the follow-up study during a period of 4 years showed transiently elevated values of SGOT and SGPT in 100 patients, persistently elevated values in 14 and normal values in 22 patients. Test for hepatitis B antigen was positive in 9 patients. Hepatomegaly, splenomegaly or both were found in 15 patients. Acute hepatitis with jaundice was reported by 23 patients, 17 of whom still showed abnormal enzyme tests. Chronic active hepatitis was very strongly suggested in 5 patients, who on repeated occasions showed, in addition to elevated SGOT and SGPT, abnormal values of serum albumins, immunoglobulins, alkaline phosphatase and Normotest. The majority of patients were free from clinical liver disease.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Four Years’ Follow-Up Study of Liver Function of Haemophiliacs ; volume:38 ; number:05 ; year:1977 ; Konferenz: XIIth Congress of The World Federation of Hemophilia; 1977-06-22; Philadelphia ; Thrombosis and haemostasis ; 38, Heft 05 (1977)

Contributors, Places and Time

• Contributor: Panicucci, F. ; Baicchi, U. ; Sagripanti, A.

Further information

• DOI: 10.1055/s-0039-1682582
• URN: urn:nbn:de:101:1-2412190851421.927587449440
• Rights: Open Access unbekannt; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:26 AM CEST