Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis

Abstract: Metabolic dysfunction‐associated fatty liver disease (MAFLD) is a complex disease involving alterations in multiple biological processes regulated by the interactions between obesity, genetic background, and environmental factors including the microbiome. To decipher hepatic steatosis (HS) pathogenesis by excluding critical confounding factors including genetic variants and diabetes, 56 heterogenous MAFLD patients are characterized by generating multiomics data including oral and gut metagenomics as well as plasma metabolomics and inflammatory proteomics data. The dysbiosis in the oral and gut microbiome is explored and the host–microbiome interactions based on global metabolic and inflammatory processes are revealed. These multiomics data are integrated using the biological network and HS's key features are identified using multiomics data. HS is finally predicted using these key features and findings are validated in a follow‐up cohort, where 22 subjects with varying degree of HS are characterized.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis ; day:07 ; month:02 ; year:2022 ; extent:20 ; Advanced science ; (07.02.2022) (gesamt 20)

Contributors, Places and Time

• Creator: Zeybel, Mujdat ; Arif, Muhammad ; Li, Xiangyu ; Altay, Ozlem ; Yang, Hong ; Shi, Mengnan ; Akyildiz, Murat ; Saglam, Burcin ; Gonenli, Mehmet Gokhan ; Yigit, Buket ; Ulukan, Burge ; Ural, Dilek ; Shoaie, Saeed ; Turkez, Hasan ; Nielsen, Jens ; Zhang, Cheng ; Uhlén, Mathias ; Borén, Jan ; Mardinoglu, Adil

Further information

• DOI: 10.1002/advs.202104373
• URN: urn:nbn:de:101:1-2022020714110400223523
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:21 AM CEST