Nickel‐Catalyzed Cascade Cyclization‐Negishi Coupling of Redox Active Esters for the Synthesis of Pyrrolidines
Abstract: We have developed a Ni‐catalyzed cascade cyclization/Negishi‐coupling reaction for the formation of pyrrolidines and pyrrolidinones starting from N‐protected allylamines and acrylamides which contain a redox active ester group. The reaction provides two C−C bonds in a single operation and takes place with both alkylzinc and arylzinc bromides as nucleophiles. Activation of RAE by low valent Ni complexes involving a radical pathway followed by a fast cyclization of intermediate carbon radicals is proposed.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Nickel‐Catalyzed Cascade Cyclization‐Negishi Coupling of Redox Active Esters for the Synthesis of Pyrrolidines ; volume:2022 ; number:44 ; year:2022 ; extent:5
European journal of organic chemistry ; 2022, Heft 44 (2022) (gesamt 5)
- Urheber
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Nieto‐Carmona, Juan Carlos
San Román, Raúl
Buñuel, Elena
Cárdenas, Diego J.
- DOI
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10.1002/ejoc.202200992
- URN
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urn:nbn:de:101:1-2022112214070025277924
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:24 MESZ
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Beteiligte
- Nieto‐Carmona, Juan Carlos
- San Román, Raúl
- Buñuel, Elena
- Cárdenas, Diego J.
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