Fusobacterium nucleatum subsp. nucleatum RadD binds Siglec-7 and inhibits NK cell-mediated cancer cell killing

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Abstract: Fusobacterium nucleatum is an oral commensal bacterium that can colonize extraoral tumor entities, such as colorectal cancer and breast cancer. Recent studies revealed its ability to modulate the immune response in the tumor microenvironment (TME), promoting cancer progression and metastasis. Importantly, F. nucleatum subsp. animalis was shown to bind to Siglec-7 via lipopolysaccharides, leading to a pro-inflammatory profile in human monocyte-derived dendritic cells. In this study, we show that F. nucleatum subsp. nucleatum RadD binds to Siglec-7 on NK cells, thereby inhibiting NK cell-mediated cancer cell killing. We demonstrate that this binding is dependent on arginine residue R124 in Siglec-7. Finally, we determine that this binding is independent of the known interaction of RadD with IgA. Taken together, our findings elucidate the targeting of Siglec-7 by F. nucleatum subsp. nucleatum RadD as a means to modulate the NK cell response and potentially promoting immune evasion and tumor progression

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: iScience. - 27, 6 (2024) , 110157, ISSN: 2589-0042

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2024

Creator: Galaski, Johanna
Rishiq, Ahmed
Liu, Mingdong
Bsoul, Reem
Bergson, Almog
Lux, Renate
Bachrach, Gilad
Mandelboim, Ofer

DOI: 10.1016/j.isci.2024.110157

URN: urn:nbn:de:bsz:25-freidok-2556754

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:44 AM CEST

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Associated

Galaski, Johanna
Rishiq, Ahmed
Liu, Mingdong
Bsoul, Reem
Bergson, Almog
Lux, Renate
Bachrach, Gilad
Mandelboim, Ofer
Universität

Time of origin

2024

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Intracellular Fusobacterium nucleatum infection attenuates antitumor immunity in esophageal squamous cell carcinoma

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Fusobacterium nucleatum subsp. nucleatum RadD binds Siglec-7 and inhibits NK cell-mediated cancer cell killing

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Other Objects (12)

[Radd ʿalā radd]

Ly6D+ Siglec-H+ precursor cells contribute to conventional dendritic cells via a Siglec-H+ Zbtb46+ Ly6D+ intermediary stage

Siglec-7/-9 ligands shield tumor cells from NK cell attack

Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9

Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Siglec ligands identify lymphocyte subpopulations and mediate immune escape of rhabdomyosarcoma cells

Identification and characterisation of a Siglec-1+ subpopulation of plasmacytoid dendritic cells

Neuroprotective Effects of Polysialic Acid and SIGLEC-11 in Activated Phagocytic Cells

Sialic acid/Siglec axis regulates antibody-mediated neutrophil cytotoxicity towards cancer cells

Intracellular Fusobacterium nucleatum infection attenuates antitumor immunity in esophageal squamous cell carcinoma

BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

[Radd ʿalā radd]

Ly6D+ Siglec-H+ precursor cells contribute to conventional dendritic cells via a Siglec-H+ Zbtb46+ Ly6D+ intermediary stage

Siglec-7/-9 ligands shield tumor cells from NK cell attack

Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9

Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Siglec ligands identify lymphocyte subpopulations and mediate immune escape of rhabdomyosarcoma cells

Identification and characterisation of a Siglec-1+ subpopulation of plasmacytoid dendritic cells

Neuroprotective Effects of Polysialic Acid and SIGLEC-11 in Activated Phagocytic Cells

Sialic acid/Siglec axis regulates antibody-mediated neutrophil cytotoxicity towards cancer cells

Intracellular Fusobacterium nucleatum infection attenuates antitumor immunity in esophageal squamous cell carcinoma

BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

[Radd ʿalā radd]

Ly6D+ Siglec-H+ precursor cells contribute to conventional dendritic cells via a Siglec-H+ Zbtb46+ Ly6D+ intermediary stage

Siglec-7/-9 ligands shield tumor cells from NK cell attack

Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9

Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Siglec ligands identify lymphocyte subpopulations and mediate immune escape of rhabdomyosarcoma cells

Identification and characterisation of a Siglec-1+ subpopulation of plasmacytoid dendritic cells

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Sialic acid/Siglec axis regulates antibody-mediated neutrophil cytotoxicity towards cancer cells

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BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

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