High‐Energy Ball Milling Enables an Ultra‐Fast Wittig Olefination Under Ambient and Solvent‐free Conditions

Abstract: 30 Seconds to success!—The Wittig reaction, a fundamental and extensively utilized reaction in organic chemistry, enables the efficient conversion of carbonyl compounds to olefins using phosphonium salts. Traditionally, meticulous reaction setup, including the pre‐formation of a reactive ylide species via deprotonation of a phosphonium salt, is crucial for achieving high‐yielding reactions under classical solution‐based conditions. In this report, we present an unprecedented protocol for an ultra‐fast mechanically induced Wittig reaction under solvent‐free and ambient conditions, often eliminating the need for tedious ylide pre‐formation under strict air and moisture exclusion. A range of aldehydes and ketones were reacted with diverse phosphonium salts under high‐energy ball milling conditions, frequently giving access to the respective olefins in only 30 seconds.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: High‐Energy Ball Milling Enables an Ultra‐Fast Wittig Olefination Under Ambient and Solvent‐free Conditions ; day:25 ; month:10 ; year:2024 ; extent:9 ; Angewandte Chemie / International edition. International edition ; (25.10.2024) (gesamt 9)

Contributors, Places and Time

• Creator: Templ, Johanna ; Schnürch, Michael

Further information

• DOI: 10.1002/anie.202411536
• URN: urn:nbn:de:101:1-2410261430587.050244557613
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:21 AM CEST