TAK-242, a toll-like receptor 4 antagonist, against brain injury by alleviates autophagy and inflammation in rats
Abstract: Inhibition of Toll-like receptor 4 (TLR4)-mediated inflammatory pathways exerts a critical effect on neuronal death; therefore, it is a possible new therapeutic approach for traumatic brain injury (TBI). Resatorvid (TAK-242) is a novel small-molecule compound widely used to inhibit TLR4-mediated pathways, but the protective mechanism of TAK-242 in TBI remains unclear. Herein, we analyzed the neuroprotective effects of TAK-242 in rats after TBI. The rat model of brain injury was established using a modified Free-fall device, and the rats were injected with TAK-242 (0.5 mg/kg) through the caudal vein before TBI. The rats were allocated into four groups: a sham group, a TBI group, a TBI + vehicle group, and a TBI + TAK-242 group. The brain tissue was extracted for histology and determination of the expression of autophagy-related proteins and inflammatory mediators. TAK-242 pretreatment significantly reduced the damage to hippocampal neurons. Neuronal autophagy increased after brain injury, whereas TAK-242 significantly reduced autophagy marker protein LC3-II in the hippocampus. In addition, TAK-242 pretreatment significantly downregulated NF-κB p65, TNF-α, and IL-1β in the hippocampus. In conclusion, TAK-242 significantly reduced hippocampal neuronal damage by inhibiting autophagy and neuroinflammatory activity, possibly via the NF-κB signaling pathway.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
TAK-242, a toll-like receptor 4 antagonist, against brain injury by alleviates autophagy and inflammation in rats ; volume:18 ; number:1 ; year:2023 ; extent:10
Open life sciences ; 18, Heft 1 (2023) (gesamt 10)
- Urheber
-
Feng, Yan
Ju, Yaru
Wu, Qiang
Sun, Guozhu
Yan, Zhongjie
- DOI
-
10.1515/biol-2022-0662
- URN
-
urn:nbn:de:101:1-2023073014021497777713
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 14.08.2025, 10:51 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Feng, Yan
- Ju, Yaru
- Wu, Qiang
- Sun, Guozhu
- Yan, Zhongjie
Ähnliche Objekte (12)
Whither new social organizations in urban China? : the structural politics of social organizations in urban China, post 1989
Brucella infection combined with Nocardia infection: A case report and literature review
Modernity criticism of aesthetic education
Socio-hydrology, politicization of water science and implication of the Eyes on Earth Study on the contemporary research dialogue in the Lancang-Mekong Basin
Application of Technological Control Measures on Vehicle Pollution: A Cost-Benefit Analysis in China
Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes
BMP4, a new prognostic factor for glioma
Wiring the Brain by Clustered Protocadherin Neural Codes
Development of wellbore compound blockage removal technology to reduce production loss in the ultra-deep and high-sulfur Yuanba gas field
An approach to predict the height of fractured water-conducting zone of coal roof strata using random forest regression
The Effect of Extracellular Vesicles on Thrombosis
Compression force promotes the osteogenic differentiation of periodontal ligament stem cells by regulating NAT10-mediated ac4C modification of BMP2
Whither new social organizations in urban China? : the structural politics of social organizations in urban China, post 1989
Brucella infection combined with Nocardia infection: A case report and literature review
Modernity criticism of aesthetic education
Socio-hydrology, politicization of water science and implication of the Eyes on Earth Study on the contemporary research dialogue in the Lancang-Mekong Basin
Application of Technological Control Measures on Vehicle Pollution: A Cost-Benefit Analysis in China
Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes
BMP4, a new prognostic factor for glioma
Wiring the Brain by Clustered Protocadherin Neural Codes
Development of wellbore compound blockage removal technology to reduce production loss in the ultra-deep and high-sulfur Yuanba gas field
An approach to predict the height of fractured water-conducting zone of coal roof strata using random forest regression
The Effect of Extracellular Vesicles on Thrombosis
Compression force promotes the osteogenic differentiation of periodontal ligament stem cells by regulating NAT10-mediated ac4C modification of BMP2
Whither new social organizations in urban China? : the structural politics of social organizations in urban China, post 1989
Brucella infection combined with Nocardia infection: A case report and literature review
Modernity criticism of aesthetic education
Socio-hydrology, politicization of water science and implication of the Eyes on Earth Study on the contemporary research dialogue in the Lancang-Mekong Basin
Application of Technological Control Measures on Vehicle Pollution: A Cost-Benefit Analysis in China
Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes
BMP4, a new prognostic factor for glioma
Wiring the Brain by Clustered Protocadherin Neural Codes
Development of wellbore compound blockage removal technology to reduce production loss in the ultra-deep and high-sulfur Yuanba gas field
An approach to predict the height of fractured water-conducting zone of coal roof strata using random forest regression
The Effect of Extracellular Vesicles on Thrombosis