Direct Synthesis of α‐Amino Acid Derivatives by Hydrative Amination of Alkynes

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Abstract: α‐Amino acid derivatives are key components of the molecules of life. The synthesis of α‐amino carbonyl/carboxyl compounds is a contemporary challenge in organic synthesis. Herein, we report a practical method for the preparation of α‐amino acid derivatives via direct hydrative amination of activated alkynes under mild conditions, relying on sulfinamides as the nitrogen source. Computational studies suggest that the reaction is enabled by a new type of sulfonium [2,3]‐sigmatropic rearrangement.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Direct Synthesis of α‐Amino Acid Derivatives by Hydrative Amination of Alkynes ; day:29 ; month:11 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (29.11.2022) (gesamt 1)

Creator: Feng, Minghao
Tinelli, Roberto
Meyrelles, Ricardo
González, Leticia
Maryasin, Boris
Maulide, Nuno

DOI: 10.1002/anie.202212399

URN: urn:nbn:de:101:1-2022113014083855706315

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:34 AM CEST

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Feng, Minghao
Tinelli, Roberto
Meyrelles, Ricardo
González, Leticia
Maryasin, Boris
Maulide, Nuno

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Direct Synthesis of α‐Amino Acid Derivatives by Hydrative Amination of Alkynes

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Other Objects (12)

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Molybdenum‐Catalyzed Asymmetric Amination of α‐Hydroxy Esters: Synthesis of α‐Amino Acids

New catalytic routes to α-amino [alpha-amino] acids and their derivatives

New catalytic routes to α-amino [alpha-amino] acids and their derivatives

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