Experimental Study on Repairing Peripheral Nerve Defects with Novel Bionic Tissue Engineering
Abstract: Peripheral nerve defects are a worldwide problem, and autologous nerve transplantation is currently the gold‐standard treatment for them. Tissue‐engineered nerve (TEN) grafts are widely considered promising methods for the same, and have attracted much attention. To improve repair, the incorporation of bionics into TEN grafts has become a focus of research. In this study, a novel bionic TEN graft with a biomimetic structure and composition is designed. For this purpose, a chitin helical scaffold is fabricated by means of mold casting and acetylation using chitosan as the raw material, following which a fibrous membrane is electrospun on the outer layer of the chitin scaffold. The lumen of the structure is filled with human bone mesenchymal stem cell‐derived extracellular matrix and fibers to provide nutrition and topographic guidance, respectively. The prepared TEN graft is then transplanted to bridge 10 mm sciatic nerve defects in rats. Morphological and functional examination shows that the repair effects of the TEN grafts and autografts are similar. The bionic TEN graft described in this study shows great potential for application and offers a new way to repair clinical peripheral nerve defects.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Experimental Study on Repairing Peripheral Nerve Defects with Novel Bionic Tissue Engineering ; day:22 ; month:03 ; year:2023 ; extent:12
Advanced healthcare materials ; (22.03.2023) (gesamt 12)
- Creator
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Qi, Tong
Zhang, Xu
Gu, Xiaosong
Cui, Shusen
- DOI
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10.1002/adhm.202203199
- URN
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urn:nbn:de:101:1-2023032314400304063127
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:04 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Qi, Tong
- Zhang, Xu
- Gu, Xiaosong
- Cui, Shusen
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