24-Hour Blood Pressure Control with Amlodipine: A Review of the Current Scenario

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Abstract: Introduction Hypertension is the leading cause of cardiovascular diseases and premature death worldwide. Antihypertensive therapy using calcium channel blockers (CCBs) is one of the preferred choices to treat blood pressure (BP) and control blood pressure variability (BPV). In contrast to clinic BP, 24-hour ambulatory BP monitoring (ABPM) has evolved into an accurate and reproducible tool for the assessment and management of hypertension. Amlodipine, a longer acting dihydropyridine CCB is effective for 24 hours BP control and also minimizing BPV. The present article is the comprehensive review highlighting the efficacy of amlodipine in controlling 24-hour BP and minimizing BPV from the review of recent studies. Materials and Methods The literature search was done using PubMed, Google Scholar, and MEDLINE databases. The studies to be included for review, were identified through the keywords: “amlodipine,” “ambulatory BP monitoring (ABPM),”“blood pressure variability (BPV),” “CCBs,” and filtering articles published in English language only. Results Pharmacological evidence suggests that amlodipine has the ability to block all the subtypes of CCBs such as L-, N-, P-, Q-, R-, and T-type. Various clinical studies reported that amlodipine is a powerful, well-tolerated, and safe antihypertensive agent which is widely used either alone or as a key component of combination therapy for control of 24 hours BP. Conclusion Overall, amlodipine is a proven and effective antihypertensive drug and helpful in controlling 24-hour BP, minimizing BP variability and hence reducing the risk of cardiovascular complications.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
24-Hour Blood Pressure Control with Amlodipine: A Review of the Current Scenario ; volume:06 ; number:01 ; year:2022 ; pages:059-068
Journal of Cardiac Critical Care TSS ; 06, Heft 01 (2022), 059-068

Contributor
Nair, Tiny
Kumar, A. Sreenivas
Unni, T. Govindan
Tiwaskar, Mangesh Harihar
Sharma, Shweta
Gaurav, Kumar

DOI
10.1055/s-0042-1750195
URN
urn:nbn:de:101:1-2022072112081507191047
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:27 AM CEST

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Associated

  • Nair, Tiny
  • Kumar, A. Sreenivas
  • Unni, T. Govindan
  • Tiwaskar, Mangesh Harihar
  • Sharma, Shweta
  • Gaurav, Kumar

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