Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research

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Abstract: Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies. The ongoing advancement of single-cell approaches, coupled with anticipated decreases in cost with increased adoption, will reshape dermatologic research, profoundly influencing disease characterization, prognosis, and ultimately clinical practice.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research ; volume:62 ; number:10 ; year:2024 ; pages:1880-1891 ; extent:12
Clinical chemistry and laboratory medicine ; 62, Heft 10 (2024), 1880-1891 (gesamt 12)

Urheber
Schepps, Samuel
Xu, Jonathan
Yang, Henry
Mandel, Jenna
Mehta, Jaanvi
Tolotta, Julianna
Baker, Nicole
Tekmen, Volkan
Nikbakht, Neda
Fortina, Paolo
Fuentes, Ignacia
LaFleur, Bonnie
Cho, Raymond J.
South, Andrew P.

DOI
10.1515/cclm-2023-1245
URN
urn:nbn:de:101:1-2409071606272.770017716735
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:26 MESZ

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Beteiligte

  • Schepps, Samuel
  • Xu, Jonathan
  • Yang, Henry
  • Mandel, Jenna
  • Mehta, Jaanvi
  • Tolotta, Julianna
  • Baker, Nicole
  • Tekmen, Volkan
  • Nikbakht, Neda
  • Fortina, Paolo
  • Fuentes, Ignacia
  • LaFleur, Bonnie
  • Cho, Raymond J.
  • South, Andrew P.

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