3D‐Printed Hollow Microneedles Array with Luer Lock Connection for Facile and Painless Intradermal Injection: A Proof of Concept
Abstract: A 3D‐printed array of hollow microneedles (HMNs) is designed and fabricated using a high‐resolution stereolithography 3D printer and assembled with a 3D‐printed reservoir that incorporates a Luer lock mechanism, ensuring standard and secure connection to syringes. The proof‐of‐concept needle designs consist of half‐eccentric and concentric conical tip shapes, each arrayed with two different interspacing values. After the geometrical features of the devices are characterized, the devices are tested ex vivo in porcine skin to evaluate the impact of tip shape and interspacing on the depth of penetration and the efficacy of the devices in delivering fluids (such as tattoo ink) into the dermis. Overall, the 3D‐printed HMNs can deliver fluids into the target layer of skin. Refinement of the design is ongoing with the ultimate aim to provide alternatives for intradermal drug delivery and diagnostic imaging, such as superficial lymphography.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
3D‐Printed Hollow Microneedles Array with Luer Lock Connection for Facile and Painless Intradermal Injection: A Proof of Concept ; day:14 ; month:06 ; year:2024 ; extent:10
Advanced Materials Technologies ; (14.06.2024) (gesamt 10)
- Urheber
-
Ghaznavi, Amirreza
Xu, Jie
Lee, Christine U.
Hara, Seth A.
- DOI
-
10.1002/admt.202400286
- URN
-
urn:nbn:de:101:1-2406151432165.711897986883
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:55 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Ghaznavi, Amirreza
- Xu, Jie
- Lee, Christine U.
- Hara, Seth A.
Ähnliche Objekte (12)
Fluid absorption by skin tissue during intradermal injections through hollow microneedles
Biocompatible 3D Printed Microneedles for Transdermal, Intradermal, and Percutaneous Applications
Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles
Intradermal Vaccination with PLGA Nanoparticles via Dissolving Microneedles and Classical Injection Needles
Perfusor-Spritze Luer-Lock 20cc Ultra-Asept
Remote‐Controlled Sensing and Drug Delivery via 3D‐Printed Hollow Microneedles
Highly Efficient Near‐IR Photothermal Microneedles with Flame‐Made Plasmonic Nanoaggregates for Reduced Intradermal Nanoparticle Deposition
Extraction and biomolecular analysis of dermal interstitial fluid collected with hollow microneedles
Lür, Lür, Leut,
Intradermal immunization
Luer
Transdermal chronopharmaceutical drug delivery: microneedles, intradermal infusion experiments and a delivery device : = Transdermale chronopharmazeutische Medikamentengabe: Mikronadeln, intradermale Infusionsversuche und ein Verabreichungssystem
Fluid absorption by skin tissue during intradermal injections through hollow microneedles
Biocompatible 3D Printed Microneedles for Transdermal, Intradermal, and Percutaneous Applications
Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles
Intradermal Vaccination with PLGA Nanoparticles via Dissolving Microneedles and Classical Injection Needles
Perfusor-Spritze Luer-Lock 20cc Ultra-Asept
Remote‐Controlled Sensing and Drug Delivery via 3D‐Printed Hollow Microneedles
Highly Efficient Near‐IR Photothermal Microneedles with Flame‐Made Plasmonic Nanoaggregates for Reduced Intradermal Nanoparticle Deposition
Extraction and biomolecular analysis of dermal interstitial fluid collected with hollow microneedles
Lür, Lür, Leut,
Intradermal immunization
Luer
Transdermal chronopharmaceutical drug delivery: microneedles, intradermal infusion experiments and a delivery device : = Transdermale chronopharmazeutische Medikamentengabe: Mikronadeln, intradermale Infusionsversuche und ein Verabreichungssystem
Fluid absorption by skin tissue during intradermal injections through hollow microneedles
Biocompatible 3D Printed Microneedles for Transdermal, Intradermal, and Percutaneous Applications
Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles
Intradermal Vaccination with PLGA Nanoparticles via Dissolving Microneedles and Classical Injection Needles
Perfusor-Spritze Luer-Lock 20cc Ultra-Asept
Remote‐Controlled Sensing and Drug Delivery via 3D‐Printed Hollow Microneedles
Highly Efficient Near‐IR Photothermal Microneedles with Flame‐Made Plasmonic Nanoaggregates for Reduced Intradermal Nanoparticle Deposition
Extraction and biomolecular analysis of dermal interstitial fluid collected with hollow microneedles
Lür, Lür, Leut,
Intradermal immunization
Luer