Smoking increases risk of complication after musculoskeletal surgery : analysis of single immune parameter to predict complication risk

Abstract: Smoking is the most significant and modifiable risk factor for a range of conditions, including cancer, cardiovascular and respiratory diseases. Furthermore, it significantly reduces bone mass and increases the risk of fragility fractures due to its detrimental effects on bone metabolism and regeneration. Moreover, smoking is a known cause of chronic systemic inflammation, leading to an imbalance of cytokines. Comprehending the pathological mechanisms that underlie cytokine production and its impact on post-surgical healing is essential to prevent post-surgical complications. The present study recruited a total of 1144 patients, including 897 patients, among them non-smokers (N = 413), current smokers (N = 201) and ex-smokers (N = 283). Human proteome profiler arrays were used to screen for smoking-dependent differences in the serum cytokine and protein profiles, after matching samples for age, gender, body mass index (BMI), alcohol use, and diabetes risk. Cytokines and immune chec.... https://www.excli.de/excli/article/view/7306

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Smoking increases risk of complication after musculoskeletal surgery ; volume:23 ; year:2024
EXCLI journal ; 23 (2024)

Creator
Tümen, Leyla
Pollmann-Schweckhorst, Lena
Breinbauer, Regina
Hammour, Mohammad M.
Aspera-Werz, Romina H.
Blumenstock, Gunnar
Histing, Tina
Menger, Maximilian M.
Ehnert, Sabrina
Nüssler, Andreas

DOI
10.17179/excli2024-7306
URN
urn:nbn:de:101:1-2411080214165.404199387587
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:33 AM CEST

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Associated

  • Tümen, Leyla
  • Pollmann-Schweckhorst, Lena
  • Breinbauer, Regina
  • Hammour, Mohammad M.
  • Aspera-Werz, Romina H.
  • Blumenstock, Gunnar
  • Histing, Tina
  • Menger, Maximilian M.
  • Ehnert, Sabrina
  • Nüssler, Andreas

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