A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors

Abstract: Information processing and storage in the brain rely on AMPA-receptors (AMPARs) and their context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution and dynamics of AMPARs in the plasma membrane are controlled by Noelins, a three-member family of conserved secreted proteins expressed throughout the brain in a cell-type-specific manner. Noelin tetramers tightly assemble with the extracellular domains of AMPARs and interconnect them in a network-like configuration with a variety of secreted and membrane-anchored proteins including Neurexin1, Neuritin1, and Seizure 6-like. Knock out of Noelins1-3 profoundly reduced AMPARs in synapses onto excitatory and inhibitory (inter)neurons, decreased their density and clustering in dendrites, and abolished activity-dependent synaptic plasticity. Our results uncover an endogenous mechanism for extracellular anchoring of AMPARs and establish Noelin-organized networks as versatile determinants of constitutive and context-dependent neurotransmission

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Neuron. - 111, 16 (2023) , 2544-2556.e9, ISSN: 1097-4199

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2023
• Creator: Boudkkazi, Sami ; Schwenk, Jochen ; Nakaya, Naoki ; Bréchet, Aline ; Kollewe, Astrid ; Harada, Harumi ; Bildl, Wolfgang ; Kulik, Akos ; Dong, Lijin ; Sultana, Afia ; Zolles, Gerd ; Schulte, Uwe ; Tomarev, Stanislav I. ; Fakler, Bernd

Further information

• DOI: 10.1016/j.neuron.2023.07.013
• URN: urn:nbn:de:bsz:25-freidok-2389187
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:46 AM CEST