Facile synthetic entry into rotationally restricted 9-arylacridines
Abstract: The treatment of 2-(trifluoromethyl) aniline with 2,6-dimethylphenylmagnesium bromide yields 1-methyl-9-(2,6-dimethylphenyl) acridine by the formal reaction of one equivalent of the aniline and two equivalents of the Grignard reagent. Interestingly, one of the methyl groups is eliminated during the reaction, and the product contains three methyl groups only. In a similar way, the reaction of 2-(trifluoromethyl) aniline with 2-ethylphenylmagnesium bromide furnishes 9-(2-ethylphenyl) acridine devoid of one ethyl group. The mechanism is discussed.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Facile synthetic entry into rotationally restricted 9-arylacridines ; volume:19 ; number:4 ; year:2013 ; pages:245-247
Heterocyclic communications ; 19, Heft 4 (2013), 245-247
- Creator
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Zhang, Jianguo
Sączewski, Jarosław
Wolińska, Ewa
Strekowski, Lucjan
- DOI
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10.1515/hc-2013-0106
- URN
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urn:nbn:de:101:1-2501130544166.386744835088
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:28 AM CEST
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Associated
- Zhang, Jianguo
- Sączewski, Jarosław
- Wolińska, Ewa
- Strekowski, Lucjan
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