miR-564 and miR-718 expressions are downregulated in colorectal cancer tissues
Objectives: MicroRNAs (miRNAs) are small RNAs that are involved in regulating gene expression and have an important role in biological pathways such as differentiation, migration, cell proliferation, and other cellular processes. Previous studies have shown that miR-564 and miR-718 are either downregulated or upregulated in various cancers. The purpose of this study was to examine the levels of expression of miR-564 and miR-718 in colorectal cancer (CRC) patients’ tumor and non-tumor tissues. Methods: The study group consisted of tumor and non-tumor tissues obtained from a total of 80 CRC patients. The expression levels of miRNAs were determined using quantitative Real-Time Polymerase Chain Reaction (RT-qPCR). Additionally, using bioinformatics analysis, the transcription factors (TFs) that are associated with miR-564 and miR-718 were identified as well as the GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment pathway analysis of these miRNAs. Results: According to the findings of RT-qPCR, both miR-564 and miR-718 expression levels were significantly downregulated in CRC (p<0.001). There was a statistically significant correlation between the expression levels of miR-564 and miR-718 (p=0.006). Both miR-564 and miR-718 regulated TFs including E2F1, HIFIA, BRD4, KDM2B, ESR1, MYC, PHF8, RUNX1, TCF12 and YY1. According to KEGG analysis, miR-564 and miR-718 were associated with Hippo and FoxO signaling pathways, respectively (p<0.05). Conclusions: miR-564 and miR-718 may have function as tumor suppressors and may be biomarkers for the diagnosis of CRC.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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miR-564 and miR-718 expressions are downregulated in colorectal cancer tissues ; volume:48 ; number:5 ; year:2023 ; pages:570-580 ; extent:11
Turkish journal of biochemistry ; 48, Heft 5 (2023), 570-580 (gesamt 11)
- Creator
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Mihcioglu, Deniz
Elihan, Erkan
Aytekin, Alper
Gurer, Turkan
- DOI
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10.1515/tjb-2023-0015
- URN
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urn:nbn:de:101:1-2023102114104113466181
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:59 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Mihcioglu, Deniz
- Elihan, Erkan
- Aytekin, Alper
- Gurer, Turkan
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