Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis
Methods: BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed. Results: The absence of IL-4 induced greater parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear cells in the host-parasite interface and intra-parenquimatous edema. The IL-4-KO animals, in the late phase of the infection, showed lower intensity of ventriculomegaly, encephalitis, and meningitis, and greater survival of the parasites in comparison with the WT animals. Conclusion: The absence of IL-4 induced lower inflammatory infiltration, ventriculomegaly and perivasculitis in experimental NCC.
- Alternative title
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Neurocisticercose experimental: ausência de IL-4 induz menos encefalite
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis ; volume:75 ; number:02 ; year:2017 ; pages:96-102
Arquivos de neuro-psiquiatria ; 75, Heft 02 (2017), 96-102
- Contributor
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Silva, Hidelberto Matos
Vinaud, Marina Clare
Lino, Ruy de Souza
- DOI
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10.1590/0004-282X20160194
- URN
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urn:nbn:de:101:1-2023101911134047008318
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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11.07.2024, 5:27 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Silva, Hidelberto Matos
- Vinaud, Marina Clare
- Lino, Ruy de Souza
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