Combined Organ Transplantation in Patients with Advanced Liver Disease
Abstract: Transplantation of the liver in combination with other organs is an increasingly performed procedure. Over the years, continuous improvement in survival could be realized through careful patient selection and refined organ preservation techniques, in spite of the challenges posed by aging recipients and donors, as well as the increased use of steatotic liver grafts. Herein, we revisit the epidemiology, allocation policies in different transplant zones, indications, and outcomes with regard to simultaneous organ transplants involving the liver, that is combined heart–liver, liver–lung, liver–kidney, and multivisceral transplantation. We address challenges surrounding combined organ transplantation such as equity, utility, and logistics of dual organ implantation, but also advantages that come along with combined transplantation, thereby focusing on molecular mechanisms underlying immunoprotection provided by the liver to the other allografts. In addition, the current standing and knowledge of machine perfusion in combined organ transplantation, mostly based on center experience, will be reviewed. Notwithstanding all the technical advances, shortage of organs, and the lack of universal eligibility criteria for certain multi-organ combinations are hurdles that need to be tackled in the future.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Combined Organ Transplantation in Patients with Advanced Liver Disease ; day:25 ; month:07 ; year:2024
Seminars in liver disease ; (25.07.2024)
- Contributor
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Zhang, Ingrid Wei
Lurje, Isabella
Lurje, Georg
Knosalla, Christoph
Schoenrath, Felix
Tacke, Frank
Engelmann, Cornelius
- DOI
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10.1055/s-0044-1788674
- URN
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urn:nbn:de:101:1-2409051203559.424308682393
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:46 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhang, Ingrid Wei
- Lurje, Isabella
- Lurje, Georg
- Knosalla, Christoph
- Schoenrath, Felix
- Tacke, Frank
- Engelmann, Cornelius
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Mechanisms of liver fibrosis resolution
Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis : mechanisms, treatment and prevention
Therapie des hepatozellulären Karzinoms – eine neue Dekade?
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Somatic mutant clone screening: scan for novel NASH target genes in mouse liver
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Untersuchung zur humoralen Regulation der Thrombopoese durch Thrombopoietin und andere Zytokine bei gesunden Probanden sowie bei Leberfunktionsstörungen und klinische Bedeutung thrombopoetischer Wachstumsfaktoren bei Patienten mit chronischen Lebererkrankungen
Zytokine, Viren, Immunzellen : Pathomechanismen und Progonosefaktoren chronischer Lebererkrankungen
Mechanisms of liver fibrosis resolution
Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis : mechanisms, treatment and prevention
Therapie des hepatozellulären Karzinoms – eine neue Dekade?
Relevance of Autophagy in Parenchymal and Non-Parenchymal Liver Cells for Health and Disease
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver
Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts
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