Visible‐Light‐Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters: Rapid Access to γ‐Amino Boronic Esters

Abstract: The synthesis of alkyl boronic esters by direct decarboxylative radical addition of carboxylic acids to vinyl boronic esters is described. The reaction proceeds under mild photoredox catalysis and involves an unprecedented single‐electron reduction of an α‐boryl radical intermediate to the corresponding anion. The reaction is amenable to a diverse range of substrates, including α‐amino, α‐oxy, and alkyl carboxylic acids, thus providing a novel method to rapidly access boron‐containing molecules of potential biological importance.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Visible‐Light‐Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters: Rapid Access to γ‐Amino Boronic Esters ; volume:130 ; number:8 ; year:2018 ; pages:2177-2181 ; extent:5
Angewandte Chemie ; 130, Heft 8 (2018), 2177-2181 (gesamt 5)

Creator
Noble, Adam
Mega, Riccardo
Pflästerer, Daniel
Myers, Eddie L.
Aggarwal, Varinder K.

DOI
10.1002/ange.201712186
URN
urn:nbn:de:101:1-2022090307451733011757
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:21 AM CEST

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