A Case of Traumatic Submacular Hemorrhage Treated with tPA and Pneumatic Displacement

This is a case of a 31-year-old female who presented to the emergency department at a London teaching hospital with a 24-h history of visual loss following an assault. The ophthalmological routine examination showed a submacular hemorrhage (SMH), and a computerized tomography scan demonstrated a displaced orbital floor fracture with inferior rectus entrapment and a medial wall fracture. To induce displacement of the SMH, intravitreal injection of 0.25 μg tissue plasminogen activator (tPA) was combined with 0.3 mL of intravitreal 100% perfluoropropane (C3F8) gas. At the 1-day follow-up, there was an inferotemporal displacement of the blood clot, and visual acuity improved from hand motions to 6/5 within 3 months. No complications occurred over 2 years of follow-up, with a final visual acuity of 6/5. This case shows us that intravitreal tPA and gas appear safe and effective as a treatment for traumatic SMHs. Furthermore, our results demonstrate that prompt treatment leads to favorable anatomical and functional outcomes.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: A Case of Traumatic Submacular Hemorrhage Treated with tPA and Pneumatic Displacement ; volume:14 ; number:1 ; year:2023 ; pages:596-601 ; extent:6 ; Case reports in ophthalmology ; 14, Heft 1 (2023), 596-601 (gesamt 6)

Contributors, Places and Time

• Creator: Motta, Lorenzo ; Ripa, Matteo ; Theodoraki, Korina ; Jackson, Timothy L. ; McHugh, Dominic

Further information

• DOI: 10.1159/000534199
• URN: urn:nbn:de:101:1-2024010323340336176037
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:36 AM CEST