The Use of Crizotinib in Sclerosing Epithelioid Fibrosarcoma with ALK Mutation: A Case Report
Sclerosing epithelioid fibrosarcoma is an ultra-rare and aggressive high-grade fibrosarcoma that was originally described in 1995. More than 100 cases are documented worldwide, with the most extensive case series reporting a high rate of recurrence and metastasis. ALK mutations are commonly seen in soft-tissue sarcomas; however, this is the first known case of an ALK V757M mutation. Here, we present a case using crizotinib in treating an ALK-positive sclerosing epithelioid fibrosarcoma refractory to all traditional treatment options.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The Use of Crizotinib in Sclerosing Epithelioid Fibrosarcoma with ALK Mutation: A Case Report ; volume:16 ; number:1 ; year:2023 ; pages:746-752 ; extent:7
Case reports in oncology ; 16, Heft 1 (2023), 746-752 (gesamt 7)
- Creator
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Badran, Ahmed
Steele, Clara
Alquaydheb, Hisham
Ba Theeb, Ahmed
Bawazir, Abdulmalek
Elshenawy, Mahmoud A.
Atallah, Jean Paul
- DOI
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10.1159/000532099
- URN
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urn:nbn:de:101:1-2023122723533616643052
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
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Associated
- Badran, Ahmed
- Steele, Clara
- Alquaydheb, Hisham
- Ba Theeb, Ahmed
- Bawazir, Abdulmalek
- Elshenawy, Mahmoud A.
- Atallah, Jean Paul
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Clinical Characteristics and efficacy of chemotherapy in sclerosing epithelioid fibrosarcoma
Sclerosing epithelioid fibrosarcoma – a rare variant with myriads of differentials
Epithelioid cell histiocytoma with SQSTM1-ALK fusion: a case report
Needle tract seeding of a sclerosing epithelioid fibrosarcoma in a biopsy tract: a case report
Identification of EML4-ALK as an alternative fusion gene in epithelioid inflammatory myofibroblastic sarcoma
Sclerosing epithelioid fibrosarcoma as a rare cause of ascites in a young man: a case report
ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation
EWSR1::ATF1 fusions characterize a group of extra-abdominal epithelioid and round cell mesenchymal neoplasms, phenotypically overlapping with sclerosing epithelioid fibrosarcomas, and intra-abdominal FET::CREB fusion neoplasms
Malignant epithelioid angiomyolipoma of the kidney with pulmonary metastases and p53 gene mutation
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Clinical Characteristics and efficacy of chemotherapy in sclerosing epithelioid fibrosarcoma
Sclerosing epithelioid fibrosarcoma – a rare variant with myriads of differentials
Epithelioid cell histiocytoma with SQSTM1-ALK fusion: a case report
Needle tract seeding of a sclerosing epithelioid fibrosarcoma in a biopsy tract: a case report
Identification of EML4-ALK as an alternative fusion gene in epithelioid inflammatory myofibroblastic sarcoma
Sclerosing epithelioid fibrosarcoma as a rare cause of ascites in a young man: a case report
ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation
EWSR1::ATF1 fusions characterize a group of extra-abdominal epithelioid and round cell mesenchymal neoplasms, phenotypically overlapping with sclerosing epithelioid fibrosarcomas, and intra-abdominal FET::CREB fusion neoplasms
Malignant epithelioid angiomyolipoma of the kidney with pulmonary metastases and p53 gene mutation
ALK
ALK