Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
1 Online-Ressource.
- Sprache
-
Englisch
- Erschienen in
-
Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting ; volume:14 ; number:1 ; day:29 ; month:11 ; year:2023 ; pages:1-16 ; date:12.2023
Nature Communications ; 14, Heft 1 (29.11.2023), 1-16, 12.2023
- Urheber
-
Ronson, George E.
Starowicz, Katarzyna
Anthony, Elizabeth J.
Piberger, Ann Liza
Clarke, Lucy C.
Garvin, Alexander J.
Beggs, Andrew D.
Whalley, Celina M.
Edmonds, Matthew J.
Beesley, James F. J.
Morris, Joanna R.
- Beteiligte Personen und Organisationen
-
SpringerLink (Online service)
- DOI
-
10.1038/s41467-023-43677-2
- URN
-
urn:nbn:de:101:1-2024021521175913489176
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:28 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Ronson, George E.
- Starowicz, Katarzyna
- Anthony, Elizabeth J.
- Piberger, Ann Liza
- Clarke, Lucy C.
- Garvin, Alexander J.
- Beggs, Andrew D.
- Whalley, Celina M.
- Edmonds, Matthew J.
- Beesley, James F. J.
- Morris, Joanna R.
- SpringerLink (Online service)
Ähnliche Objekte (12)
The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells
Exploiting Synthetic lethality between Germline BRCA1 haploinsufficiency and PARP inhibition in JAK2V617F-positive myeloproliferative neoplasms
Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection
Modeling synthetic lethality
The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis
Immunoglobulin subclass deficiencies
Are There Deficiencies?
Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi
DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis
![[Theta]](https://iiif.deutsche-digitale-bibliothek.de/image/2/1fb6d2e8-9409-4153-ac92-32404629de02/full/!306,450/0/default.jpg)
[Theta]
Prevention of endotoxin-induced lethality, but not of liver apoptosis in Poly(ADP-ribose) polymerase-deficient mice
Phenylketonuria and BH4 deficiencies
The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells
Exploiting Synthetic lethality between Germline BRCA1 haploinsufficiency and PARP inhibition in JAK2V617F-positive myeloproliferative neoplasms
Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection
Modeling synthetic lethality
The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis
Immunoglobulin subclass deficiencies
Are There Deficiencies?
Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi
DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis
[Theta]
Prevention of endotoxin-induced lethality, but not of liver apoptosis in Poly(ADP-ribose) polymerase-deficient mice
Phenylketonuria and BH4 deficiencies
The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells
Exploiting Synthetic lethality between Germline BRCA1 haploinsufficiency and PARP inhibition in JAK2V617F-positive myeloproliferative neoplasms
Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection
Modeling synthetic lethality
The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis
Immunoglobulin subclass deficiencies
Are There Deficiencies?
Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi
DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis
[Theta]
Prevention of endotoxin-induced lethality, but not of liver apoptosis in Poly(ADP-ribose) polymerase-deficient mice