MOG-IgG associated optic neuritis is not multiple sclerosis

Abstract: Autoantibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with inflammatory central nervous system disorders including isolated optic neuritis (ON). We compared our MOG-IgG ON patients with multiple sclerosis (MS) patients presenting with ON. Methods and results: Among the total of 38 patients with optic neuropathies, six patients with isolated ON were MOG-IgG positive and eight patients with ON fulfilled the diagnostic criteria for MS. All MS patients were negative for MOG-IgG using a cell-based assay. When compared with the MS group, the MOG-IgG patients were older (mean 47 years), more frequently male (ratio 2:1) and had a higher frequency of bilateral and/or recurrent ON. The brain magnetic resonance imaging of all MOG-IgG positive patients was normal or had only unspecific white matter T2 lesions. Conclusion: These findings suggest that MOG-IgG is a biomarker of an inflammatory demyelinating CNS disease distinct from MS.

Object Details

• Alternative title: Neurite óptica associada ao MOG-IgG não é esclerose múltipla
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: MOG-IgG associated optic neuritis is not multiple sclerosis ; volume:75 ; number:10 ; year:2017 ; pages:687-691 ; Arquivos de neuro-psiquiatria ; 75, Heft 10 (2017), 687-691

Contributors, Places and Time

• Contributor: Costa, Bruna Klein da ; Passos, Giordani Rodrigues dos ; Becker, Jefferson ; Sato, Douglas Kazutoshi

Further information

• DOI: 10.1590/0004-282X20170121
• URN: urn:nbn:de:101:1-2023101910430560638581
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:02 AM CEST