Chronic restraint stress impairs cognition via modulating HDAC2 expression
Background: To investigate the effects of chronic restraint stress on cognition and the probable molecular mechanism in mice. Methods: In the current work, a restraining tube was used as a way to induce chronic stress in mice. The protein levels were determined with ELISA and western blot. A series of behavior tests, including the Morris water maze, elevated plus maze, open field test, and novel object recognition test, were also performed to examine the anxiety and the ability of learning and memory. Moreover, murine neuroblastoma N2a cells were used to confirm the findings from mice under chronic stress. Results: Decreased synaptic functions were impaired in chronic stress with the downregulation of PSD95, GluR-1, the neurotrophic factor BDNF, and immediate-onset genes Arc and Egr. Chronic restraint decreased the histone acetylation level in hippocampal neurons while HDAC2 was increased and was co-localized with glucocorticoid receptors. Moreover, chronic stress inhibited the PI3K/AKT signaling pathway and induced energy metabolism dysfunctions. Conclusion: This work examining the elevated levels of HDAC2 in the hippocampus may provide new insights and targets for drug development for treating many neurodegenerative diseases.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Chronic restraint stress impairs cognition via modulating HDAC2 expression ; volume:12 ; number:1 ; year:2021 ; pages:154-163 ; extent:10
Translational Neuroscience ; 12, Heft 1 (2021), 154-163 (gesamt 10)
- Urheber
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Wu, Jie
Liu, Cui
Zhang, Ling
He, Bing
Shi, Wei-Ping
Shi, Hai-Lei
Qin, Chuan
- DOI
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10.1515/tnsci-2020-0168
- URN
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urn:nbn:de:101:1-2022082914433912794437
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:31 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Wu, Jie
- Liu, Cui
- Zhang, Ling
- He, Bing
- Shi, Wei-Ping
- Shi, Hai-Lei
- Qin, Chuan
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