Targeting Gut Bacteria Using Inulin‐Conjugated Mesoporous Silica Nanoparticles

Abstract: To facilitate the creation of novel nanocarrier systems targeting the intestinal microbiome, inulin‐conjugated mesoporous silica nanoparticles (MSNs) are described herein for the first time. Surface functionalization is achieved on either hydrophilic or hydrophobic mesoporous nanoparticles using different conjugation methods. The targeting performance of the resulting materials is assessed and compared upon incubation with human stool. It appears that amide formation is the most favorable coupling method on hydrophilic MSNs to achieve the desired bioconjugate. Remarkably, high affinity of gut bacteria to the conjugated particles can be obtained, paving the way to novel targeted drug delivery systems.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Targeting Gut Bacteria Using Inulin‐Conjugated Mesoporous Silica Nanoparticles ; day:17 ; month:04 ; year:2022 ; extent:11 ; Advanced materials interfaces ; (17.04.2022) (gesamt 11)

Contributors, Places and Time

• Creator: von Baeckmann, Cornelia ; Riva, Alessandra ; Guggenberger, Patrick ; Kählig, Hanspeter ; Han, Seung Won ; Inan, Deniz ; Del Favero, Giorgia ; Berry, David ; Kleitz, Freddy

Further information

• DOI: 10.1002/admi.202102558
• URN: urn:nbn:de:101:1-2022041815050791538421
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:31 AM CEST