Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies

Abstract: Hepatic encephalopathy (HE) is a potentially reversible neuropsychiatric syndrome. Often, HE causes cognitive and motor dysfunctions due to an acute or chronic insufficiency of the liver or a shunting between the hepatic portal vein and systemic vasculature. Liver damage induces peripheral changes, such as in the metabolism and peripheral inflammatory responses that trigger exacerbated neuroinflammation. In experimental models, anti-inflammatory strategies have demonstrated neuroprotective effects, leading to a reduction in HE-related cognitive and motor impairments. In this scenario, a growing body of evidence has shown that peripheral and central nervous system inflammation are promising preclinical targets. In this review, we performed an overview of FDA-approved drugs and natural compounds which are used in the treatment of other neurological and nonneurological diseases that have played a neuroprotective role in experimental HE, at least in part, through anti-inflammatory mechanisms. Despite the exciting results from animal models, the available data should be critically interpreted, highlighting the importance of translating the findings for clinical essays.

Angaben zum Objekt

• Weitere Titel: Estratégias anti-inflamatórias para encefalopatia hepática: estudos pré-clínicos
• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies ; volume:81 ; number:07 ; year:2023 ; pages:656-669 ; Arquivos de neuro-psiquiatria ; 81, Heft 07 (2023), 656-669

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: Santos, Rafaela Pinto Coelho ; Toscano, Eliana Cristina de Brito ; Rachid, Milene Alvarenga

Weitere Informationen

• DOI: 10.1055/s-0043-1767819
• URN: urn:nbn:de:101:1-2023090710575009648783
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:52 MESZ