Biomimetic Lipopolysaccharide‐Free Bacterial Outer Membrane‐Functionalized Nanoparticles for Brain‐Targeted Drug Delivery
Abstract: The blood–brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia coli K1 (EC‐K1) binding to and invasion of BBB endothelial cells in bacterial meningitis, utilization of the BBB invasion ability of the EC‐K1 outer membrane for brain‐targeted drug delivery and construction of a biomimetic self‐assembled nanoparticle with a surface featuring a lipopolysaccharide‐free EC‐K1 outer membrane are proposed. BBB penetration of biomimetic nanoparticles is demonstrated to occur through the transcellular vesicle transport pathway, which is at least partially dependent on internalization, endosomal escape, and transcytosis mediated by the interactions between outer membrane protein A and gp96 on BBB endothelial cells. This biomimetic nanoengineering strategy endows the loaded drugs with prolonged circulation, intracranial interstitial distribution, and extremely high biocompatibility. Based on the critical roles of gp96 in cancer biology, this strategy reveals enormous potential for delivering therapeutics to treat gp96‐overexpressing intracranial malignancies.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Biomimetic Lipopolysaccharide‐Free Bacterial Outer Membrane‐Functionalized Nanoparticles for Brain‐Targeted Drug Delivery ; day:31 ; month:03 ; year:2022 ; extent:15
Advanced science ; (31.03.2022) (gesamt 15)
- Creator
-
Chen, Haiyan
Zhou, Mengyuan
Zeng, Yuteng
Miao, Tongtong
Luo, Haoyuan
Tong, Yang
Zhao, Mei
Mu, Rui
Gu, Jiang
Yang, Shudi
Han, Liang
- DOI
-
10.1002/advs.202105854
- URN
-
urn:nbn:de:101:1-2022040415191123202659
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:31 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Chen, Haiyan
- Zhou, Mengyuan
- Zeng, Yuteng
- Miao, Tongtong
- Luo, Haoyuan
- Tong, Yang
- Zhao, Mei
- Mu, Rui
- Gu, Jiang
- Yang, Shudi
- Han, Liang
Other Objects (12)
Biomimetic Liposomal Nanoplatinum for Targeted Cancer Chemophototherapy
Biomimetic mercury immobilization by selenium functionalized polyphenylene sulfide fabric
Lipopolysaccharide assembly in the bacterial outer membrane revealed by X-ray crystallography
Lipopolysaccharide directly inhibits bicarbonate absorption by the renal outer medullary collecting duct
Development of functionalized electrospun fibers as biomimetic artificial basement membranes
Platelet-membrane-biomimetic nanoparticles for targeted antitumor drug delivery
RGD peptide modified RBC membrane functionalized biomimetic nanoparticles for thrombolytic therapy
Structure of the outer membrane protein FhuA presents a binding mode for Lipopolysaccharide
Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs
Biomimetic nanoparticle-driven strategies for targeted drug delivery in glioblastoma
A Bioactive Synthetic Outer‐Core Oligosaccharide Derived from a Klebsiella pneumonia Lipopolysaccharide for Bacteria Recognition
Increasing outer membrane complexity: the case of the lipopolysaccharide lipid A from marine Cellulophaga pacifica
Biomimetic Liposomal Nanoplatinum for Targeted Cancer Chemophototherapy
Biomimetic mercury immobilization by selenium functionalized polyphenylene sulfide fabric
Lipopolysaccharide assembly in the bacterial outer membrane revealed by X-ray crystallography
Lipopolysaccharide directly inhibits bicarbonate absorption by the renal outer medullary collecting duct
Development of functionalized electrospun fibers as biomimetic artificial basement membranes
Platelet-membrane-biomimetic nanoparticles for targeted antitumor drug delivery
RGD peptide modified RBC membrane functionalized biomimetic nanoparticles for thrombolytic therapy
Structure of the outer membrane protein FhuA presents a binding mode for Lipopolysaccharide
Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs
Biomimetic nanoparticle-driven strategies for targeted drug delivery in glioblastoma
A Bioactive Synthetic Outer‐Core Oligosaccharide Derived from a Klebsiella pneumonia Lipopolysaccharide for Bacteria Recognition
Increasing outer membrane complexity: the case of the lipopolysaccharide lipid A from marine Cellulophaga pacifica
Biomimetic Liposomal Nanoplatinum for Targeted Cancer Chemophototherapy
Biomimetic mercury immobilization by selenium functionalized polyphenylene sulfide fabric
Lipopolysaccharide assembly in the bacterial outer membrane revealed by X-ray crystallography
Lipopolysaccharide directly inhibits bicarbonate absorption by the renal outer medullary collecting duct
Development of functionalized electrospun fibers as biomimetic artificial basement membranes
Platelet-membrane-biomimetic nanoparticles for targeted antitumor drug delivery
RGD peptide modified RBC membrane functionalized biomimetic nanoparticles for thrombolytic therapy
Structure of the outer membrane protein FhuA presents a binding mode for Lipopolysaccharide
Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs
Biomimetic nanoparticle-driven strategies for targeted drug delivery in glioblastoma
A Bioactive Synthetic Outer‐Core Oligosaccharide Derived from a Klebsiella pneumonia Lipopolysaccharide for Bacteria Recognition