lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p

Abstract: Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported as an oncogene in many tumors including retinoblastoma (RB). This research mainly focused on the functions and mechanism of MALAT1 in RB. MALAT1 was upregulated in RB tissues and cells, and it served as a competing endogenous RNA (ceRNA) and inhibited miRNA-655-3p (miR-655-3p) expression, which eventually regulated the expression of miR-655-3p downstream target ATPase Family AAA Domain Containing 2 (ATAD2). The level of ATAD2 significantly increased, while that of miR-655-3p remarkably decreased in RB tissues and cells. MALAT1 depletion inhibited cell proliferation, metastasis, and epithelial–mesenchymal transition (EMT), but promoted apoptosis in vitro and blocked xenograft tumor growth in vivo. MALAT1 exerted its oncogenic functions in RB by regulating miR-655-3p/ATAD2 axis.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: lncRNA MALAT1 regulated ATAD2 to facilitate retinoblastoma progression via miR-655-3p ; volume:16 ; number:1 ; year:2021 ; pages:931-943 ; extent:13 ; Open medicine ; 16, Heft 1 (2021), 931-943 (gesamt 13)

Contributors, Places and Time

• Creator: Zhao, Yuxin ; Wang, Zhaoxia ; Gao, Meili ; Wang, Xuehong ; Feng, Hui ; Cui, Yuanyuan ; Tian, Xia

Further information

• DOI: 10.1515/med-2021-0290
• URN: urn:nbn:de:101:1-2022092015404407086021
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:38 AM CEST