Hydride Reduction by a Sodium Hydride–Iodide Composite

Abstract: Sodium hydride (NaH) is widely used as a Brønsted base in chemical synthesis and reacts with various Brønsted acids, whereas it rarely behaves as a reducing reagent through delivery of the hydride to polar π electrophiles. This study presents a series of reduction reactions of nitriles, amides, and imines as enabled by NaH in the presence of LiI or NaI. This remarkably simple protocol endows NaH with unprecedented and unique hydride‐donor chemical reactivity.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Hydride Reduction by a Sodium Hydride–Iodide Composite ; volume:55 ; number:11 ; year:2016 ; pages:3719-3723 ; extent:5 ; Angewandte Chemie / International edition. International edition ; 55, Heft 11 (2016), 3719-3723 (gesamt 5)

Contributors, Places and Time

• Creator: Too, Pei Chui ; Chan, Guo Hao ; Tnay, Ya Lin ; Hirao, Hajime ; Chiba, Shunsuke

Further information

• DOI: 10.1002/anie.201600305
• URN: urn:nbn:de:101:1-2022110106090566940975
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:34 AM CEST