Intravitreal melphalan for persistent retinoblastoma vitreous seeds
Abstract: A 7-month-old male presented with bilateral retinoblastoma, initially group E OD and group C OS (International Intraocular Retinoblastoma Classification). The patient underwent enucleation with adjuvant chemotherapy and radiotherapy on the right eye for extraocular retinoblastoma. The main tumors on the left eye regressed with combined neoadjuvant chemotherapy with focal therapy, but had persistent sphere vitreous seeds overlying the tumor at the superotemporal mid-periphery and at the inferior periphery. Intravitreal injection of melphalan was performed. Vitreous seeds were clinically undetectable after 2 cycles of injection. Six months from the 2nd intravitreal injection of melphalan, there was no evidence of new tumors nor vitreous seeds in the left eye. No documented complications of intravitreal melphalan injection were experienced. This is the first documented successful treatment of vitreous seeds with intravitreal melphalan at the Ocular Oncology/Retinoblastoma Unit of the...
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Intravitreal melphalan for persistent retinoblastoma vitreous seeds ; volume:12 ; day:08 ; month:02 ; year:2022
GMS ophthalmology cases ; 12 (08.02.2022)
- Classification
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Medizin, Gesundheit
- Creator
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Redondo-Villanueva, Marie Jeazelle H.
Mercado, Gary John V.
- DOI
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10.3205/oc000190
- URN
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urn:nbn:de:0183-oc0001900
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Redondo-Villanueva, Marie Jeazelle H.
- Mercado, Gary John V.
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Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma
Orthotopic transplantation of retinoblastoma cells into vitreous cavity of zebrafish for screening of anticancer drugs
Atypical anterior persistent hyperplastic primary vitreous: report of a rare case
Ocular toxicity of intravitreal melphalan for retinoblastoma in Chinese patients
Intravitreal ziv-aflibercept in diabetic vitreous hemorrhage
Diffuse chorioretinal atrophy after a single standard low- dose intravitreal melphalan injection in a child with retinoblastoma: a case report
Vitreous opacities after intravitreal triamcinolone injection- a case report
Primary Vitreoretinal Lymphoma Therapy Monitoring: Significant Vitreous Haze Reduction After Intravitreal Rituximab
Bilateral primary hyperplastic persistent vitreous: report of two cases
Case report: tuberous sclerosis and persistent hyperplastic primary vitreous
Vitreous changes after intravitreal bevacizumab monotherapy for retinopathy of prematurity: a case series
Reoperation following vitrectomy for diabetic vitreous hemorrhage with versus without preoperative intravitreal bevacizumab
Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma
Orthotopic transplantation of retinoblastoma cells into vitreous cavity of zebrafish for screening of anticancer drugs
Atypical anterior persistent hyperplastic primary vitreous: report of a rare case
Ocular toxicity of intravitreal melphalan for retinoblastoma in Chinese patients
Intravitreal ziv-aflibercept in diabetic vitreous hemorrhage
Diffuse chorioretinal atrophy after a single standard low- dose intravitreal melphalan injection in a child with retinoblastoma: a case report
Vitreous opacities after intravitreal triamcinolone injection- a case report
Primary Vitreoretinal Lymphoma Therapy Monitoring: Significant Vitreous Haze Reduction After Intravitreal Rituximab
Bilateral primary hyperplastic persistent vitreous: report of two cases
Case report: tuberous sclerosis and persistent hyperplastic primary vitreous
Vitreous changes after intravitreal bevacizumab monotherapy for retinopathy of prematurity: a case series
Reoperation following vitrectomy for diabetic vitreous hemorrhage with versus without preoperative intravitreal bevacizumab
Effectiveness of intravitreal chemotherapy-assisted endoresection in monocular patients with group D retinoblastoma
Orthotopic transplantation of retinoblastoma cells into vitreous cavity of zebrafish for screening of anticancer drugs