Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications
Abstract: Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post‐translational modifications controlling virtually all cellular processes. What was once regarded as a mere signal for protein degradation has turned out to be a major regulator of molecular signalling networks. Deregulation of ubiquitin signalling is closely associated with various human pathologies. Here, we summarize the current knowledge of ubiquitin signalling in immune deficiencies and cancer as well as the available therapeutic strategies targeting the ubiquitin system in combating these pathogenic conditions.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications ; volume:4 ; number:7 ; year:2012 ; pages:545-556 ; extent:12
EMBO molecular medicine / European Molecular Biology Organization ; 4, Heft 7 (2012), 545-556 (gesamt 12)
- DOI
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10.1002/emmm.201100707
- URN
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urn:nbn:de:101:1-2023022404523264803172
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:50 AM CEST
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Ubiquitin – klein, aber oho! : Markierungsvarianten des winzigen Proteins entscheiden über Wohl und Wehe von Zellen
Autophagy in cancer therapy
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications
Die antiproliferative Wirkung von Alkylanzien, Platinderivaten, Antimetaboliten und Zilascorb auf sechs humane neuroektodermale Zellinien in vitro
Modulation of Apoptosis by Natural Products for Cancer Therapy
Cell death pathways as therapeutic targets in rhabdomyosarcoma
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Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways using Petri nets
Manatee invariants reveal functional pathways in signaling networks
Manatee invariants reveal functional pathways in signaling networks
Endosomes
Open questions : why should we care about ER-phagy and ER remodelling?
Ubiquitin – klein, aber oho! : Markierungsvarianten des winzigen Proteins entscheiden über Wohl und Wehe von Zellen