IL‐4/IL‐13‐producing ILC2s are required for timely control of intestinal helminth infection in mice
Abstract: Infection of mice with Nippostrongylus brasiliensis (Nb) serves as a model for human hookworm infection affecting about 600 million people world‐wide. Expulsion of Nb from the intestine requires IL‐13‐mediated mucus secretion from goblet cells and activation of smooth muscles cells. Type 2 innate lymphoid cells (ILC2s) are a major cellular source of IL‐13 but it remains unclear whether IL‐13 secretion from ILC2s is required for Nb expulsion. Here, we compared the immune response to Nb infection in mixed bone marrow chimeras with wild‐type or IL‐4/IL‐13‐deficient ILC2s. ILC2‐derived IL‐4/IL‐13 was required for recruitment of eosinophils to the lung but had no influence of systemic eosinophil levels. In the small intestine, goblet cell hyperplasia and tuft cell accumulation was largely dependent on IL‐4/IL‐13 secretion from ILC2s. This further translated to higher eggs counts and impaired worm expulsion in mice with IL‐4/IL‐13‐deficient ILC2s. Overall, we demonstrate that ILC2s constitute a non‐redundant source of IL‐4/IL‐13 required for protective immunity against primary Nb infection.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
IL‐4/IL‐13‐producing ILC2s are required for timely control of intestinal helminth infection in mice ; day:28 ; month:09 ; year:2022 ; extent:9
European journal of immunology ; (28.09.2022) (gesamt 9)
- Urheber
-
Varela, Filipa
Symowski, Cornelia
Pollock, Jonathan
Wirtz, Stefan
Voehringer, David
- DOI
-
10.1002/eji.202249892
- URN
-
urn:nbn:de:101:1-2022092815190153707735
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:20 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Varela, Filipa
- Symowski, Cornelia
- Pollock, Jonathan
- Wirtz, Stefan
- Voehringer, David
Ähnliche Objekte (12)
IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections
Antagonism between IL-4 and IL-10 in colitis and a helminth infection in Mus musculus
The IL-17-IL-17RA axis is required to promote osteosarcoma progression in mice
Tissue adaptation of IL-17-producing γδ T cells
IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse
IL-4 mediated conditioning of human dendritic cell precursors to become IL-12p70 producing DC
IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity
IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
Characterization of IL-17-producing enthesis-resident γδ T cells
IL-17A producing mast cells as therapeutic target in spondyloarthritis
Helminth-induced IL-4 expands bystander memory CD8 + T cells for early control of viral infection
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2
IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections
Antagonism between IL-4 and IL-10 in colitis and a helminth infection in Mus musculus
The IL-17-IL-17RA axis is required to promote osteosarcoma progression in mice
Tissue adaptation of IL-17-producing γδ T cells
IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse
IL-4 mediated conditioning of human dendritic cell precursors to become IL-12p70 producing DC
IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity
IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
Characterization of IL-17-producing enthesis-resident γδ T cells
IL-17A producing mast cells as therapeutic target in spondyloarthritis
Helminth-induced IL-4 expands bystander memory CD8 + T cells for early control of viral infection
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2
IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections
Antagonism between IL-4 and IL-10 in colitis and a helminth infection in Mus musculus
The IL-17-IL-17RA axis is required to promote osteosarcoma progression in mice
Tissue adaptation of IL-17-producing γδ T cells
IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse
IL-4 mediated conditioning of human dendritic cell precursors to become IL-12p70 producing DC
IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity
IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
Characterization of IL-17-producing enthesis-resident γδ T cells
IL-17A producing mast cells as therapeutic target in spondyloarthritis
Helminth-induced IL-4 expands bystander memory CD8 + T cells for early control of viral infection