Pharmacological inhibition of mTORC2 reduces migration and metastasis in melanoma
Abstract: Despite recent advances in therapy, liver metastasis from melanoma is still associated with poor prognosis. Although targeting the mTOR signaling pathway exerts potent anti-tumor activity, little is known about specific mTORC2 inhibition regarding liver metastasis. Using the novel mTORC2 specific inhibitor JR-AB2-011, we show significantly reduced migration and invasion capacity by impaired activation of MMP2 in melanoma cells. In addition, blockade of mTORC2 induces cell death by non-apoptotic pathways and reduces tumor cell proliferation rate dose-dependently. Furthermore, a significant reduction of liver metastasis was detected in a syngeneic murine metastasis model upon therapy with JR-AB2-011 as determined by in vivo imaging and necropsy. Hence, our study for the first time highlights the impact of the pharmacological blockade of mTORC2 as a potent novel anti-cancer approach for liver metastasis from melanoma
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
International journal of molecular sciences. - 22, 1 (2021) , 30, ISSN: 1422-0067
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2021
- DOI
-
10.3390/ijms22010030
- URN
-
urn:nbn:de:bsz:25-freidok-1748021
- Rechteinformation
-
Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
25.03.2025, 13:54 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Günzle, Jessica
- Akasaka, Harue
- Jöchle, Katharina
- Reichardt, Wilfried
- Venkatasamy, Aïna
- Höppner, Jens
- Hellerbrand, Claus
- Fichtner-Feigl, Stefan
- Lang, Sven Arke
- Universität
Entstanden
- 2021
Ähnliche Objekte (12)
Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma
Inhibition of mTORC2/RICTOR impairs melanoma hepatic metastasis
Platelet surface receptors and melanoma metastasis
Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy
Liver-specific endothelial mechanisms of melanoma metastasis
Role of melanoma-derived ADAM-9 for invasion and metastasis of melanoma
Neutrophilic inflammation promotes angiotropism and metastasis in melanoma
Osteocytes support bone metastasis of melanoma cells by CXCL5
A mechanistic evaluation of melanoma metastasis and therapy resistance
Melanoma-associated brain metastasis: Molecular mechanisms and therapeutic options
Cellular pharmacological inhibition of enveloped virus entry
Osteocytes support bone metastasis of melanoma cells by Secreting CXCL5
Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma
Inhibition of mTORC2/RICTOR impairs melanoma hepatic metastasis
Platelet surface receptors and melanoma metastasis
Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy
Liver-specific endothelial mechanisms of melanoma metastasis
Role of melanoma-derived ADAM-9 for invasion and metastasis of melanoma
Neutrophilic inflammation promotes angiotropism and metastasis in melanoma
Osteocytes support bone metastasis of melanoma cells by CXCL5
A mechanistic evaluation of melanoma metastasis and therapy resistance
Melanoma-associated brain metastasis: Molecular mechanisms and therapeutic options
Cellular pharmacological inhibition of enveloped virus entry
Osteocytes support bone metastasis of melanoma cells by Secreting CXCL5
Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma
Inhibition of mTORC2/RICTOR impairs melanoma hepatic metastasis
Platelet surface receptors and melanoma metastasis
Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy
Liver-specific endothelial mechanisms of melanoma metastasis
Role of melanoma-derived ADAM-9 for invasion and metastasis of melanoma
Neutrophilic inflammation promotes angiotropism and metastasis in melanoma
Osteocytes support bone metastasis of melanoma cells by CXCL5
A mechanistic evaluation of melanoma metastasis and therapy resistance
Melanoma-associated brain metastasis: Molecular mechanisms and therapeutic options
Cellular pharmacological inhibition of enveloped virus entry