Regiodivergent Arylation of Pyridines via Zincke Intermediates
Abstract: An arylation protocol for pyridines is described, via the ring‐opened Zincke intermediate. Treatment of pyridines with triflic anhydride and a secondary amine produces an azahexatriene species, which undergoes regioselective Pd‐catalyzed arylation at the putative C4 position. Recyclization then provides the pyridine products. Alternatively, metal‐free arylation with a diaryliodonium salt is selective for the pyridine meta‐position, affording a regiodivergent approach to pyridine biaryls from a common intermediate.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Regiodivergent Arylation of Pyridines via Zincke Intermediates ; day:11 ; month:01 ; year:2024 ; extent:5
Angewandte Chemie / International edition. International edition ; (11.01.2024) (gesamt 5)
- Creator
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Wang, Haiwen
Greaney, Michael F.
- DOI
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10.1002/anie.202315418
- URN
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urn:nbn:de:101:1-2024011214183453724392
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:33 AM CEST
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Associated
- Wang, Haiwen
- Greaney, Michael F.
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