Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
Abstract: General methods to prepare chiral N‐heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2‐ and 4‐substituted tetrahydro‐quinolones, dihydro‐4‐pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors ; volume:131 ; number:37 ; year:2019 ; pages:13084-13088 ; extent:5
Angewandte Chemie ; 131, Heft 37 (2019), 13084-13088 (gesamt 5)
- Creator
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Guo, Yafei
Harutyunyan, Syuzanna R.
- DOI
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10.1002/ange.201906237
- URN
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urn:nbn:de:101:1-2022073112360227357480
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:28 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Guo, Yafei
- Harutyunyan, Syuzanna R.
Other Objects (12)
Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
Copper-catalysed alkylation of heterocyclic acceptors with organometallic reagents
Structure and Reactivity of N‐Heterocyclic Alkynyl Hypervalent Iodine Reagents
N-Heterocyclic carbenes
N‐Heterocyclic Carbenes and N‐Heterocycles as Synthetic Reagents and Building Blocks
Transnitrilation of Grignard Reagents and Aryllithiums
Iron-Catalyzed Alkylations of Aromatic Grignard Reagents
Special topic N-heterocyclic carbenes
Oxidative N-heterocyclic carbene catalysis
N-heterocyclic carbenes in organocatalysis
Oxidative N‐Heterocyclic Carbene Catalysis
NON‐Ligated N‐Heterocyclic Tetrylenes
Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
Copper-catalysed alkylation of heterocyclic acceptors with organometallic reagents
Structure and Reactivity of N‐Heterocyclic Alkynyl Hypervalent Iodine Reagents
N-Heterocyclic carbenes
N‐Heterocyclic Carbenes and N‐Heterocycles as Synthetic Reagents and Building Blocks
Transnitrilation of Grignard Reagents and Aryllithiums
Iron-Catalyzed Alkylations of Aromatic Grignard Reagents
Special topic N-heterocyclic carbenes
Oxidative N-heterocyclic carbene catalysis
N-heterocyclic carbenes in organocatalysis
Oxidative N‐Heterocyclic Carbene Catalysis
NON‐Ligated N‐Heterocyclic Tetrylenes
Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors
Copper-catalysed alkylation of heterocyclic acceptors with organometallic reagents
Structure and Reactivity of N‐Heterocyclic Alkynyl Hypervalent Iodine Reagents
N-Heterocyclic carbenes
N‐Heterocyclic Carbenes and N‐Heterocycles as Synthetic Reagents and Building Blocks
Transnitrilation of Grignard Reagents and Aryllithiums
Iron-Catalyzed Alkylations of Aromatic Grignard Reagents
Special topic N-heterocyclic carbenes
Oxidative N-heterocyclic carbene catalysis
N-heterocyclic carbenes in organocatalysis
Oxidative N‐Heterocyclic Carbene Catalysis