Angiogenesis by BMP-2-PDLLA-Biohybrids in Co-Culture with Osteoblasts and Endothelia
Abstract: Adsorbate biohybrids for BMP-2 delivery based on electrospun PDLLA-nanofiber fleeces loaded with 0.6 μg/cm2 rhBMP-2COL (E. coli) strongly induced microvessel- like structures when incubated for 14 days in cocultures of human outgrowth endothelial cells (OEC) together with human primary osteoblasts (pOB). Higher loaded rhBMP-2COL biohybrids (4.6 μg/cm2) were low- to noninductive. Adsorbate biohybrids of rhBMP-2CHO (CHO cells) loaded with 1.0-6.0 μg/cm2 induced only a classic cobblestone- like growth pattern without any microvessels. Concentration- response experiments (7 days) indicate a binding affinity of rhBMP-2COL for microvessel induction in the picomolar range with nanomolar concentrations being non-inductive
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Angiogenesis by BMP-2-PDLLA-Biohybrids in Co-Culture with Osteoblasts and Endothelia ; volume:7 ; number:2 ; year:2021 ; pages:835-838 ; extent:4
Current directions in biomedical engineering ; 7, Heft 2 (2021), 835-838 (gesamt 4)
- Urheber
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Dohle, Eva
Sowislok, Andrea
Ghanaati, Shahram
Jennissen, Herber P.
- DOI
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10.1515/cdbme-2021-2213
- URN
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urn:nbn:de:101:1-2022101214034348230247
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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2025-08-15T07:28:43+0200
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Beteiligte
- Dohle, Eva
- Sowislok, Andrea
- Ghanaati, Shahram
- Jennissen, Herber P.
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