From Immunogenic Peptides to Intrinsically Disordered Proteins

Abstract: It is hard to evaluate the role of individual mentors in the genesis of important ideas. In the case of our realization that proteins do not have to be stably folded to be functional, the influence of Richard Lerner and our collaborative work in the 1980s on the conformations of immunogenic peptides provided a base level of thinking about the nature of polypeptides in water solutions that led us to formulate and develop our ideas on the importance of intrinsic disorder in proteins. This review describes how the insights gained into the behavior of peptides led directly to the realization that proteins were not only capable of being functional while disordered, but also that disorder provided a distinct functional advantage in many important cellular processes.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: From Immunogenic Peptides to Intrinsically Disordered Proteins ; day:11 ; month:05 ; year:2023 ; extent:9 ; Israel journal of chemistry ; (11.05.2023) (gesamt 9)

Beteiligte, Orts- und Zeitangaben

• Urheber: Dyson, H. Jane ; Wright, Peter E.

Weitere Informationen

• DOI: 10.1002/ijch.202300051
• URN: urn:nbn:de:101:1-2023051115501928446389
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:48 MESZ