Empowering personalized medicine : unleashing the potential of patient-derived explants in clinical practice
Abstract: In recent decades, significant progress has been made in understanding the molecular characteristics of cancer and its microenvironment, leading to the development of life-saving treatments. However, patients often experience side effects from standard therapies, highlighting the need for personalized medicine. Personalized medicine aims to customize drug therapy and preventive care based on individual patients' specific requirements. The heterogeneity within tumors and among patients necessitates personalized medicine approaches. Patient-derived organoids (PDOs), xenografts (PDXs), and explants (PDEs) have emerged as valuable models for studying tumor behaviour and drug response. This paper aims to summarize the latest advancements in patient-derived explants, focusing on their potential utility in the clinic. Different methods for culturing PDEs, including the free-floating approach, the grid method, and sponge scaffolds, are discussed. These approaches provide opportunities for .... https://www.excli.de/index.php/excli/article/view/6700
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Empowering personalized medicine ; volume:23 ; year:2024
EXCLI journal ; 23 (2024)
- Creator
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Piwocka, Oliwia
Suchorska, Wiktoria M.
Kulcenty, Katarzyna
- DOI
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10.17179/excli2023-6700
- URN
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urn:nbn:de:101:1-2024030802150320623399
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:52 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Piwocka, Oliwia
- Suchorska, Wiktoria M.
- Kulcenty, Katarzyna
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