A new meiosis‐specific cohesin complex implicated in the cohesin code for homologous pairing

We identify a new mammalian cohesin subunit, RAD21‐like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not‐yet‐synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo‐like kinase 1, which is similar to the mitotic prophase pathway.
RAD21L is identified as a new meiosis‐specific cohesin with a unique spatiotemporal distribution. RAD21L and REC8 have symmetrical, mutually exclusive localization on the not‐yet‐synapsed homologues, implying that cohesins could establish a code for homologue recognition.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: A new meiosis‐specific cohesin complex implicated in the cohesin code for homologous pairing ; volume:12 ; number:3 ; year:2011 ; pages:267-275 ; extent:9 ; EMBO reports / European Molecular Biology Organization ; 12, Heft 3 (2011), 267-275 (gesamt 9)

Contributors, Places and Time

• Creator: Ishiguro, Kei‐ichiro ; Kim, Jihye ; Fujiyama‐Nakamura, Sally ; Kato, Shigeaki ; Watanabe, Yoshinori

Further information

• DOI: 10.1038/embor.2011.2
• URN: urn:nbn:de:101:1-2023032109482827677475
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:46 AM CEST