Rh (III)‐Catalyzed C‐2 Alkylation of Indoles followed by a Post‐Synthetic Modification via the Ugi Reaction

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Abstract: Indole derivatives substituted at the C‐2 position have shown important biological activities. Due to these properties, several methods have been described for the preparation of structurally diverse indoles. In this work, we have synthesized highly functionalized indole derivatives via Rh (III)‐catalyzed C‐2 alkylation with nitroolefins. Under the optimized condition, 23 examples were prepared with 39–80 % yield. Moreover, the nitro compounds were reduced and submitted to the Ugi four‐component reaction, furnishing a series of new indole‐peptidomimetics in moderate to good overall yields.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Rh (III)‐Catalyzed C‐2 Alkylation of Indoles followed by a Post‐Synthetic Modification via the Ugi Reaction ; volume:12 ; number:6 ; year:2023 ; extent:8
ChemistryOpen ; 12, Heft 6 (2023) (gesamt 8)

Urheber
Januário, Marcelo Augusto Pereira
de Souza, Demetrius P.
Zukerman‐Schpector, Julio
Corrêa, Arlene G.

DOI
10.1002/open.202300070
URN
urn:nbn:de:101:1-2023060815174311376796
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 11:00 MESZ

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Beteiligte

  • Januário, Marcelo Augusto Pereira
  • de Souza, Demetrius P.
  • Zukerman‐Schpector, Julio
  • Corrêa, Arlene G.

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