Fabrication of Gentamicin Sulfate‐Loaded 3D‐Printed Polyvinyl Alcohol/Sodium Alginate/Gelatin‐Methacryloyl Hybrid Scaffolds for Skin Tissue Replacement
Abstract: 3D‐printed scaffolds can better mimic the function of human skin, both biologically and mechanically. Within the scope of this study, the effect of the addition of different amounts (10, 15, 20 mg) of gentamicin sulfate (GS) to a 10 mL solution of natural and synthetic polymers is investigated. Sodium alginate (SA), gelatin‐methacryloyl (GelMA), and polyvinyl alcohol (PVA) are chosen as bioactive materials. The surface morphology and pore structures are visualized by scanning electron microscopy (SEM). According to the results, it is observed that the pore sizes of all scaffolds are smaller than 270 µm, the lowest value (130 µm) is obtained in the scaffold loaded with 15 mg GS, and it also has the highest tensile strength value (12.5 ± 7.6 MPa). Similarly, it is observed that the tensile strength (9.7 ± 4.5 MPa) is high in scaffold loaded with 20 mg GS. The biocompatibility test is performed with fibroblast cells, and the results show that the scaffolds are biocompatible with cells. The antibacterial test is carried out against the S.aureous and E. coli and the results indicate that all GS‐loaded scaffolds demonstrate antibacterial activity.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Fabrication of Gentamicin Sulfate‐Loaded 3D‐Printed Polyvinyl Alcohol/Sodium Alginate/Gelatin‐Methacryloyl Hybrid Scaffolds for Skin Tissue Replacement ; day:24 ; month:10 ; year:2023 ; extent:9
Macromolecular materials and engineering ; (24.10.2023) (gesamt 9)
- Urheber
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Izgordu, Muhammet Sefa
Ayran, Musa
Ulag, Songul
Yildirim, Ridvan
Bulut, Berrak
Sahin, Ali
Guncu, Mehmet Mucahit
Aksu, Burak
Gunduz, Oguzhan
- DOI
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10.1002/mame.202300151
- URN
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urn:nbn:de:101:1-2023102515215732621749
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:48 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Izgordu, Muhammet Sefa
- Ayran, Musa
- Ulag, Songul
- Yildirim, Ridvan
- Bulut, Berrak
- Sahin, Ali
- Guncu, Mehmet Mucahit
- Aksu, Burak
- Gunduz, Oguzhan
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