Reductive amination of 6-acetylpteridine to 6- N -arylaminoethylpteridine
Abstract: 6-Acetyl-7-methylpteridine derivatives 2 and 3 (lumazine and pterin) were converted to 6-[1-(arylamino) ethyl]pteridine derivatives 8 and 7, respectively, in good to moderate yields by stepwise reactions with p-substituted anilines via imine intermediates using a Lewis acid catalyst followed by treatment with sodium tetrahydroborate. The one-step reductive amination of the starting acetylpteridine also proceeded in the presence of 2-picoline-borane complex in satisfactory yield.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Reductive amination of 6-acetylpteridine to 6- N -arylaminoethylpteridine ; volume:18 ; number:3 ; year:2012 ; pages:117-122
Heterocyclic communications ; 18, Heft 3 (2012), 117-122
- Creator
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Kuroda, Yasuhiro
Isarai, Kazuhiro
Murata, Shizuaki
- DOI
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10.1515/hc-2012-0046
- URN
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urn:nbn:de:101:1-2501130536190.775061597062
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
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Associated
- Kuroda, Yasuhiro
- Isarai, Kazuhiro
- Murata, Shizuaki
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