Phase Transitions in Chemically Fueled, Multiphase Complex Coacervate Droplets

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Abstract: Membraneless organelles are droplets in the cytosol that are regulated by chemical reactions. Increasing studies suggest that they are internally organized. However, how these subcompartments are regulated remains elusive. Herein, we describe a complex coacervate‐based model composed of two polyanions and a short peptide. With a chemical reaction cycle, we control the affinity of the peptide for the polyelectrolytes leading to distinct regimes inside the phase diagram. We study the transitions from one regime to another and identify new transitions that can only occur under kinetic control. Finally, we show that the chemical reaction cycle controls the liquidity of the droplets offering insights into how active processes inside cells play an important role in tuning the liquid state of membraneless organelles. Our work demonstrates that not only thermodynamic properties but also kinetics should be considered in the organization of multiple phases in droplets.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Phase Transitions in Chemically Fueled, Multiphase Complex Coacervate Droplets ; day:18 ; month:10 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (18.10.2022) (gesamt 1)

Creator: Donau, Carsten
Späth, Fabian
Stasi, Michele
Bergmann, Alexander M.
Boekhoven, Job

DOI: 10.1002/anie.202211905

URN: urn:nbn:de:101:1-2022101915215222683556

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:22 AM CEST

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Associated

Donau, Carsten
Späth, Fabian
Stasi, Michele
Bergmann, Alexander M.
Boekhoven, Job

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