Massive Intoxication with 70 Tablets of Apixaban: A Case Report

Abstract: Apixaban is a direct oral anticoagulation agent that exerts its effect through the direct inhibition of factor Xa. We treated a case of massive intoxication with 70 tablets of apixaban and have presented the clinical course of the associated anti-Xa activities. A 49-year-old woman was admitted to the emergency department approximately 1.5 h after impulsive self-intoxication with 175 mg of apixaban. She developed coagulopathy with prothrombin time-international normalized ratio (PT-INR) of 3.65, activated partial thromboplastin time of 56.5 s, and antithrombin activity (AT) of >150% (at 1.5 h post-ingestion). The patient’s initial and peak anti-Xa activity was 17.7 IU/mL, and its elimination displayed first-order kinetics with a half-life of 10.5 h. The patient’s anti-Xa activity was within the therapeutic dose range at 26 h post-ingestion, and she recovered without experiencing any bleeding complications. Her coagulopathy also returned to normal level at the same timing. This result suggests that PT-INR and AT can be used as substitute markers of overwhelmed anticoagulation following massive overdose of apixaban. A case of apixaban overdose with associated anti-Xa activities was presented. There was favorable resolution of anticoagulation without specific treatments.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Massive Intoxication with 70 Tablets of Apixaban: A Case Report ; volume:6 ; number:1 ; year:2023 ; pages:13-18 ; extent:6 ; Case reports in acute medicine ; 6, Heft 1 (2023), 13-18 (gesamt 6)

Beteiligte, Orts- und Zeitangaben

• Urheber: Kobayashi, Tadahiro ; Saito, Satoko ; Takada, Masayuki ; Sakaguchi, Kento ; Takahashi, Kazunori ; Tanaka, Ken ; Kawamae, Kaneyuki ; Nakane, Masaki

Weitere Informationen

• DOI: 10.1159/000533520
• URN: urn:nbn:de:101:1-2407110013222.342985349526
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:44 MESZ