Synthesis of polysubstituted pyridines as potential multidrug resistance modulators
Abstract: Polysubstituted pyridines 4 bearing methoxyphenyl groups at different positions of the ring have been prepared by the alkylation of 6-thioxo-1,6-dihydropyridines 1 or by the oxidation of 1,4-dihydropyridine 6 with manganese triacetate. The multidrug resistance–modulating (P-glycoprotein inhibition) activity of pyridine derivatives 4 comparable with that of verapamil has been revealed.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Synthesis of polysubstituted pyridines as potential multidrug resistance modulators ; volume:21 ; number:2 ; year:2015 ; pages:93-96 ; extent:4
Heterocyclic communications ; 21, Heft 2 (2015), 93-96 (gesamt 4)
- Urheber
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Krauze, Aivars
Grinberga, Signe
Sokolova, Elina
Domracheva, Ilona
Shestakova, Irina
Duburs, Gunars
- DOI
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10.1515/hc-2015-0037
- URN
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urn:nbn:de:101:1-2501130618330.129020737708
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:23 MESZ
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Beteiligte
- Krauze, Aivars
- Grinberga, Signe
- Sokolova, Elina
- Domracheva, Ilona
- Shestakova, Irina
- Duburs, Gunars
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