Synthesis of polysubstituted pyridines as potential multidrug resistance modulators

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Abstract: Polysubstituted pyridines 4 bearing methoxyphenyl groups at different positions of the ring have been prepared by the alkylation of 6-thioxo-1,6-dihydropyridines 1 or by the oxidation of 1,4-dihydropyridine 6 with manganese triacetate. The multidrug resistance–modulating (P-glycoprotein inhibition) activity of pyridine derivatives 4 comparable with that of verapamil has been revealed.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Synthesis of polysubstituted pyridines as potential multidrug resistance modulators ; volume:21 ; number:2 ; year:2015 ; pages:93-96 ; extent:4
Heterocyclic communications ; 21, Heft 2 (2015), 93-96 (gesamt 4)

Creator: Krauze, Aivars
Grinberga, Signe
Sokolova, Elina
Domracheva, Ilona
Shestakova, Irina
Duburs, Gunars

DOI: 10.1515/hc-2015-0037

URN: urn:nbn:de:101:1-2501130618330.129020737708

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:23 AM CEST

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Krauze, Aivars
Grinberga, Signe
Sokolova, Elina
Domracheva, Ilona
Shestakova, Irina
Duburs, Gunars

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Synthesis of polysubstituted pyridines as potential multidrug resistance modulators

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Other Objects (12)

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