Metal Free Bi (hetero) aryl Synthesis: A Benzyne Truce–Smiles Rearrangement

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Abstract: A new benzyne transformation is described that affords versatile biaryl structures without recourse to transition‐metal catalysis or stoichiometric amounts of organometallic building blocks. Aryl sulfonamides add to benzyne upon fluoride activation, and then undergo an aryl Truce–Smiles rearrangement to afford biaryls with sulfur dioxide extrusion. The reaction proceeds under simple reaction conditions and has excellent scope for the synthesis of sterically hindered atropisomeric biaryl amines.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Metal Free Bi (hetero) aryl Synthesis: A Benzyne Truce–Smiles Rearrangement ; volume:128 ; number:7 ; year:2016 ; pages:2496-2499 ; extent:4
Angewandte Chemie ; 128, Heft 7 (2016), 2496-2499 (gesamt 4)

Urheber
Holden, Catherine M.
Sohel, Shariar M. A.
Greaney, Michael F.

DOI
10.1002/ange.201510236
URN
urn:nbn:de:101:1-2022101006575402062336
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:35 MESZ

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Beteiligte

  • Holden, Catherine M.
  • Sohel, Shariar M. A.
  • Greaney, Michael F.

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