Metabolomic analysis of the human placenta reveals perturbations in amino acids, purine metabolites, and small organic acids in spontaneous preterm birth
Abstract: Spontaneous preterm delivery presents one of the most complex challenges in obstetrics and is a leading cause of perinatal morbidity and mortality. Although it is a common endpoint for multiple pathological processes, the mechanisms governing the etiological complexity of spontaneous preterm birth and the placental responses are poorly understood. This study examined placental tissues collected between May 2019 and May 2022 from a well-defined cohort of women who experienced spontaneous preterm birth (n = 72) and healthy full-term deliveries (n = 30). Placental metabolomic profiling of polar metabolites was performed using Ultra-High Performance Liquid Chromatography/Mass Spectrometry (UHPLC/MS) analysis. The resulting data were analyzed using multi- and univariate statistical methods followed by unsupervised clustering. A comprehensive metabolomic evaluation of the placenta revealed that spontaneous preterm birth was associated with significant changes in the levels of 34 polar me.... https://www.excli.de/index.php/excli/article/view/6785
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Metabolomic analysis of the human placenta reveals perturbations in amino acids, purine metabolites, and small organic acids in spontaneous preterm birth ; volume:23 ; year:2024
EXCLI journal ; 23 (2024)
- Urheber
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Cifkova, Eva
Karahoda, Rona
Stranik, Jaroslav
Abad, Cilia
Kacerovsky, Marian
Lisa, Miroslav
Staud, Frantisek
- DOI
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10.17179/excli2023-6785
- URN
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urn:nbn:de:101:1-2024030802160418291610
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:53 MESZ
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Beteiligte
- Cifkova, Eva
- Karahoda, Rona
- Stranik, Jaroslav
- Abad, Cilia
- Kacerovsky, Marian
- Lisa, Miroslav
- Staud, Frantisek
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