Neutrophils Enable Local and Non‐Invasive Liposome Delivery to Inflamed Skeletal Muscle and Ischemic Heart
Abstract: Uncontrolled inflammation is a major pathological factor underlying a range of diseases including autoimmune conditions, cardiovascular disease, and cancer. Improving localized delivery of immunosuppressive drugs to inflamed tissue in a non‐invasive manner offers significant promise to reduce severe side effects caused by systemic administration. Here, a neutrophil‐mediated delivery system able to transport drug‐loaded nanocarriers to inflamed tissue by exploiting the inherent ability of neutrophils to migrate to inflammatory tissue is reported. This hybrid system (neutrophils loaded with liposomes ex vivo) efficiently migrates in vitro following an inflammatory chemokine gradient. Furthermore, the triggered release of loaded liposomes and reuptake by target macrophages is studied. The migratory behavior of liposome‐loaded neutrophils is confirmed in vivo by demonstrating the delivery of drug‐loaded liposomes to an inflamed skeletal muscle in mice. A single low‐dose injection of the hybrid system locally reduces inflammatory cytokine levels. Biodistribution of liposome‐loaded neutrophils in a human‐disease‐relevant myocardial ischemia reperfusion injury mouse model after i.v. injection confirms the ability of injected neutrophils to carry loaded liposomes to inflammation sites. This strategy shows the potential of nanocarrier‐loaded neutrophils as a universal platform to deliver anti‐inflammatory drugs to promote tissue regeneration in inflammatory diseases.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Neutrophils Enable Local and Non‐Invasive Liposome Delivery to Inflamed Skeletal Muscle and Ischemic Heart ; volume:32 ; number:48 ; year:2020 ; extent:10
Advanced materials ; 32, Heft 48 (2020) (gesamt 10)
- Urheber
-
Che, Junyi
Najer, Adrian
Blakney, Anna K.
McKay, Paul F.
Bellahcene, Mohamed
Winter, Charles W.
Sintou, Amalia
Tang, Jiaqing
Keane, Timothy J.
Schneider, Michael D.
Shattock, Robin J.
Sattler, Susanne
Stevens, Molly
- DOI
-
10.1002/adma.202003598
- URN
-
urn:nbn:de:101:1-2022061413020939037916
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:35 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Che, Junyi
- Najer, Adrian
- Blakney, Anna K.
- McKay, Paul F.
- Bellahcene, Mohamed
- Winter, Charles W.
- Sintou, Amalia
- Tang, Jiaqing
- Keane, Timothy J.
- Schneider, Michael D.
- Shattock, Robin J.
- Sattler, Susanne
- Stevens, Molly
Ähnliche Objekte (12)
Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium
Human and mouse neutrophils share core transcriptional programs in both homeostatic and inflamed contexts
Scale-up of liposome manufacturing : combining high pressure liposome extrusion with drying technologies
Scale-up of liposome manufacturing : combining high pressure liposome extrusion with drying technologies
Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation
Liposome-based drug delivery systems
Liposome dermatics : with 48 tables
Engineering a nanoscale liposome-in-liposome for in situ biochemical synthesis and multi-stage release
Liposome retention in size exclusion chromatography
Toll-Like Receptor Expression Profile Of Gingival Mesenchymal Stem Cells In Inflamed And Non-Inflamed Conditions
Heterogeneity Among Neutrophils
An inflamed necrotic appendix epiploicum with immediate contact to a non-inflamed appendix vermiformis: a case report
Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium
Human and mouse neutrophils share core transcriptional programs in both homeostatic and inflamed contexts
Scale-up of liposome manufacturing : combining high pressure liposome extrusion with drying technologies
Scale-up of liposome manufacturing : combining high pressure liposome extrusion with drying technologies
Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation
Liposome-based drug delivery systems
Liposome dermatics : with 48 tables
Engineering a nanoscale liposome-in-liposome for in situ biochemical synthesis and multi-stage release
Liposome retention in size exclusion chromatography
Toll-Like Receptor Expression Profile Of Gingival Mesenchymal Stem Cells In Inflamed And Non-Inflamed Conditions
Heterogeneity Among Neutrophils
An inflamed necrotic appendix epiploicum with immediate contact to a non-inflamed appendix vermiformis: a case report
Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium
Human and mouse neutrophils share core transcriptional programs in both homeostatic and inflamed contexts
Scale-up of liposome manufacturing : combining high pressure liposome extrusion with drying technologies
Scale-up of liposome manufacturing : combining high pressure liposome extrusion with drying technologies
Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation
Liposome-based drug delivery systems
Liposome dermatics : with 48 tables
Engineering a nanoscale liposome-in-liposome for in situ biochemical synthesis and multi-stage release
Liposome retention in size exclusion chromatography
Toll-Like Receptor Expression Profile Of Gingival Mesenchymal Stem Cells In Inflamed And Non-Inflamed Conditions
Heterogeneity Among Neutrophils