Mass Spectrometry Imaging of Organoids to Improve Preclinical Research
Abstract: Preclinical models are essential research tools before novel therapeutic or diagnostic methods can be applied to humans. These range from in vitro cell monocultures to vastly more complex animal models, but clinical translation to humans often fails to deliver significant results. Three‐dimensional (3D) organoid systems are being increasingly studied to establish physiologically relevant in vitro platforms in a trade‐off between the complexity of the research question and the complexity of practical experimental setups. The sensitivity and precision of analytical tools are yet another limiting factors in what can be investigated, and mass spectrometry (MS) is one of the most powerful analytical techniques available to the scientific community. Its innovative use to spatially resolve biological samples has opened many research avenues in the field of MS imaging (MSI). Here, this work aims to explore the current scientific landscape in the application of MSI on organoids, with an emphasis on their combined potential to facilitate and improve preclinical studies.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Mass Spectrometry Imaging of Organoids to Improve Preclinical Research ; day:05 ; month:02 ; year:2024 ; extent:9
Advanced healthcare materials ; (05.02.2024) (gesamt 9)
- Creator
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Zivko, Cristina
Hahm, Tae‐Hun
Tressler, Cay
Brown, Dalton
Glunde, Kristine
Mahairaki, Vasiliki
- DOI
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10.1002/adhm.202302499
- URN
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urn:nbn:de:101:1-2024020614032130303543
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:20 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zivko, Cristina
- Hahm, Tae‐Hun
- Tressler, Cay
- Brown, Dalton
- Glunde, Kristine
- Mahairaki, Vasiliki
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