Efficient synthesis of 2,4-disubstituted thiazoles and 2-substituted 4-thiazolidinones under solvent free conditions

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Abstract: Condensation of thiosemicarbazones 2 derived from 1-tetralones (1) with chloroacetic acid in presence of N-methylpyridinium tosylate (an ionic liquid) yields 2-substituted-4-thiazolidinones 3. The reaction of 2 with α-halo carbonyl compounds at room temperature under grinding conditions yields 2,4-disubstituted thiazoles 4 in excellent yields. The structures of compounds 2–4 have been established on the basis of elemental analysis, IR, NMR and mass spectral data.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Efficient synthesis of 2,4-disubstituted thiazoles and 2-substituted 4-thiazolidinones under solvent free conditions ; volume:17 ; number:3-4 ; year:2011 ; pages:147-150
Heterocyclic communications ; 17, Heft 3-4 (2011), 147-150

Creator: Gautam, Deepika
Gautam, Poonam
Chaudhary, Ram P.

DOI: 10.1515/hc.2011.027

URN: urn:nbn:de:101:1-2501140245262.987814763436

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:34 AM CEST

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Gautam, Deepika
Gautam, Poonam
Chaudhary, Ram P.

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Efficient synthesis of 2,4-disubstituted thiazoles and 2-substituted 4-thiazolidinones under solvent free conditions

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Other Objects (12)

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